INT26116

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 42
Disease Relevance 13.97
Pain Relevance 20.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
spinal cord 3
brain 3
dorsal horn 3
neuronal 3
neurons 3
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 188 100.00 Very High Very High Very High
Calcitonin gene-related peptide 101 100.00 Very High Very High Very High
adenocard 41 100.00 Very High Very High Very High
Ventral tegmentum 231 99.98 Very High Very High Very High
substance P 102 99.90 Very High Very High Very High
Desipramine 30 99.84 Very High Very High Very High
cytokine 11 99.74 Very High Very High Very High
gABA 347 99.70 Very High Very High Very High
Dorsal horn 45 99.68 Very High Very High Very High
Nicotine 134 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 96 99.96 Very High Very High Very High
Urological Neuroanatomy 194 99.92 Very High Very High Very High
Convulsion 504 99.80 Very High Very High Very High
Apoptosis 200 99.66 Very High Very High Very High
INFLAMMATION 35 99.56 Very High Very High Very High
Epilepsy 164 99.18 Very High Very High Very High
Ganglion Cysts 230 98.48 Very High Very High Very High
Pain 232 97.78 Very High Very High Very High
Injury 28 96.56 Very High Very High Very High
Nociception 130 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because previous reports suggest these agents may influence gamma-aminobutyric acid (GABA) neurotransmission, and GABAB receptors are known to participate in the transmission of pain impulses, the present experiments were undertaken to examine whether the administration of desipramine alters GABAB receptor subunit expression and function in the dorsal horn of the rat spinal cord.
Gene_expression (expression) of GABAB in spinal cord associated with pain, desipramine, gaba, dorsal horn and spinal cord
1) Confidence 0.78 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.24 Pain Relevance 0.85
Moreover, it was found that 7 days of treatment with desipramine enhances GABAB receptor function, as measured by baclofen-stimulated [35S]GTPgammaS binding, and increases mRNA expression for the GABAB(1a) and GABAB(2), but not GABAB(1b), subunits.
Gene_expression (expression) of GABAB associated with desipramine
2) Confidence 0.67 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.22 Pain Relevance 1.01
Moreover, it was found that 7 days of treatment with desipramine enhances GABAB receptor function, as measured by baclofen-stimulated [35S]GTPgammaS binding, and increases mRNA expression for the GABAB(1a) and GABAB(2), but not GABAB(1b), subunits.
Gene_expression (expression) of GABAB associated with desipramine
3) Confidence 0.67 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.22 Pain Relevance 1.01
Relationship between the antinociceptive response to desipramine and changes in GABAB receptor function and subunit expression in the dorsal horn of the rat spinal cord.
Gene_expression (expression) of GABAB in dorsal horn associated with desipramine, analgesic, dorsal horn, antinociceptive and spinal cord
4) Confidence 0.60 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 14757174 Disease Relevance 0.24 Pain Relevance 0.94
Moreover, it was found that 7 days of treatment with desipramine enhances GABAB receptor function, as measured by baclofen-stimulated [35S]GTPgammaS binding, and increases mRNA expression for the GABAB(1a) and GABAB(2), but not GABAB(1b), subunits.
Gene_expression (expression) of GABAB associated with desipramine
5) Confidence 0.59 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.22 Pain Relevance 1.02
However, we have previously demonstrated that GABAB receptor expression and coupling to G-proteins in the ventral tegmental area of the rat are not altered after chronic exposure to nicotine [52], suggesting that desensitisation might occur at other levels, perhaps on downstream effector mechanisms.
Gene_expression (expression) of GABAB in ventral associated with ventral tegmentum and nicotine
6) Confidence 0.48 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.72
In addition, in vivo microdialysis studies have demonstrated that intra-VTA administration of the GABAB receptor agonist baclofen decreases extracellular dopamine levels in both the somatodendritic [32,33] and the axon-terminal regions of the mesocorticolimbic system [15,16].
Gene_expression (administration) of GABAB associated with ventral tegmentum, dopamine and agonist
7) Confidence 0.41 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 1.04
Expression of all GABAB subunits was observed in both the spinal cord and IML samples (n?
Gene_expression (Expression) of GABAB in spinal cord associated with urological neuroanatomy and spinal cord
8) Confidence 0.40 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.55 Pain Relevance 0.19
These results indicate that THA blocks the actions of baclofen and GABA at post- but not presynaptic GABAB receptors.
Neg (not) Gene_expression (presynaptic) of GABAB associated with gaba
9) Confidence 0.39 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8096243 Disease Relevance 0.43 Pain Relevance 0.50
The effects of the K+ channel blocker 9-amino-1,2,3,4-tetrahydroacridine (THA) on the actions of baclofen and gamma-aminobutyric acid (GABA) at post- and presynaptic GABAB receptors were studied with whole-cell voltage-clamp recording in area CA3 of rat hippocampal slices. 2.
Gene_expression (presynaptic) of GABAB associated with gaba
10) Confidence 0.39 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8096243 Disease Relevance 0 Pain Relevance 0.19
The GABAB receptor agonist baclofen, administered spinally, produced antinociception in the tail-flick test, whereas the GABAA receptor agonist isoguvacine did not.
Gene_expression (produced) of GABAB receptor in tail
11) Confidence 0.39 Published 2002 Journal Anesthesiology Section Body Doc Link 11981157 Disease Relevance 0.19 Pain Relevance 0
This finding represents the first demonstration that chronic exposure to nicotine might result in reduced GABAB-mediated inhibition of VTA dopaminergic neurones.
Gene_expression (reduced) of GABAB associated with ventral tegmentum and nicotine
12) Confidence 0.36 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.89
GABAB subunits are expressed in the IML of spinal cord
Gene_expression (expressed) of GABAB in spinal cord associated with urological neuroanatomy and spinal cord
13) Confidence 0.35 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.52 Pain Relevance 0.16
Presynaptic GABAB receptors are not tonically activated
Gene_expression (Presynaptic) of GABAB
14) Confidence 0.35 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.27 Pain Relevance 0.34
GABAB receptors are present postsynaptically on SPNs and high concentrations of the GABAB agonist, baclofen (10–100??
Gene_expression (present) of GABAB associated with agonist
15) Confidence 0.35 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.26 Pain Relevance 0.59
There are developmental changes in GABAB receptor subunits since GABAB1(a) is predominant during embryonic period and at birth whilst GABAB1(b) expression increases during the first postnatal month in the brain (Fritschy et al., 1994).
Gene_expression (expression) of GABAB receptor in brain
16) Confidence 0.35 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.10
Presynaptic GABAB heteroreceptors have been reported on excitatory terminals onto SPNs by Cheng's group and others (Cheng et al., 2005; Wu and Dun, 1992).
Gene_expression (Presynaptic) of GABAB
17) Confidence 0.35 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.13 Pain Relevance 0.34
In fact evidence suggests that presynaptic GABAB receptors are mainly comprised of GABAB1a/GABAB2 subunits (Billinton et al., 1999; Towers et al., 2000), so pharmacological differences would be unexpected.
Gene_expression (presynaptic) of GABAB
18) Confidence 0.35 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.30
There are developmental changes in GABAB receptor subunits since GABAB1(a) is predominant during embryonic period and at birth whilst GABAB1(b) expression increases during the first postnatal month in the brain (Fritschy et al., 1994).
Gene_expression (expression) of GABAB1 in brain
19) Confidence 0.30 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.07
 ; GABAB2 reverse 5?
Gene_expression (reverse) of GABAB2
20) Confidence 0.30 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.08 Pain Relevance 0.07

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