INT261209

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Context Info
Confidence 0.73
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.61
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) transport (Apoa1) extracellular space (Apoa1)
extracellular region (Apoa1) nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
liver 1
superior 1
astrocytes 1
Apoa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 7 79.36 Quite High
Multiple sclerosis 48 73.12 Quite High
rheumatoid arthritis 17 69.48 Quite High
Inflammation 22 65.60 Quite High
Sciatic nerve 1 60.80 Quite High
cytokine 10 57.00 Quite High
imagery 6 36.56 Quite Low
Inflammatory response 1 24.96 Low Low
Demyelination 2 8.64 Low Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 94 100.00 Very High Very High Very High
Injury 2 95.84 Very High Very High Very High
Demyelinating Disease 59 91.28 High High
Ovarian Cancer 54 89.20 High High
Communicable Diseases 4 89.08 High High
Rupture 2 74.80 Quite High
Acute Coronary Syndrome 16 70.88 Quite High
Disease 47 70.56 Quite High
Systemic Lupus Erythematosus 19 69.80 Quite High
Rheumatoid Arthritis 17 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In recent years, some researchers conformed that astrocytes generated apoA-I and apoE in rat, apoA-I facilitated translocation of newly synthesized cholesterol and phospholipid to cytosol to form the lipid-protein complex particles as an initial event in cholesterol trafficking for the assembly of HDL, and found cholesterol efflux from rat astrocytes induced by apoA-I and apoE.
Localization (translocation) of apoA-I in astrocytes associated with disorder of lipid metabolism
1) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 0.87 Pain Relevance 0.30
Pitavastatin was noted to have superior ApoA1 secretion-promoting effect as compared to atorvastatin and simvastatin.
Localization (secretion) of ApoA1 in superior
2) Confidence 0.25 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.50 Pain Relevance 0.03
This result showed pitavastatin inhibited the secretion of VLDL, one of the TG-rich lipoproteins, from the liver.15 In addition, the effect on the secretion of ApoA1, a constituent of HDL, from the liver was evaluated using HepG2 cells.
Localization (secretion) of ApoA1 in liver associated with disorder of lipid metabolism
3) Confidence 0.25 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.41 Pain Relevance 0
Using a training set of 91 stage I data sets, representing 61 individual samples, and an equivalent number of controls, an 11-analyte profile, composed of CA-125, CA 19-9, EGF-R, C-reactive protein, myoglobin, apolipoprotein A1, apolipoprotein CIII, MIP-1?
Localization (apolipoprotein A1) of apolipoprotein A1 associated with disorder of lipid metabolism
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2643010 Disease Relevance 0.82 Pain Relevance 0

General Comments

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