INT26123

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Context Info
Confidence 0.23
First Reported 1989
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.22
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ep300) transferase activity, transferring acyl groups (Ep300) DNA binding (Ep300)
transcription factor binding (Ep300) cytoplasm (Ep300)
Ep300 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 10 100.00 Very High Very High Very High
Dopamine 2 99.52 Very High Very High Very High
Neurotransmitter 2 99.48 Very High Very High Very High
GABAergic 2 95.80 Very High Very High Very High
Pain 14 94.08 High High
Catecholamine 2 75.00 Quite High
depression 25 55.60 Quite High
imagery 7 53.16 Quite High
Morphine 3 5.00 Very Low Very Low Very Low
phantom limb 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 10 94.08 High High
Depression 34 91.32 High High
Cognitive Disorder 2 76.96 Quite High
Neurodegenerative Disease 2 71.00 Quite High
Motor Neuron Diseases 34 53.28 Quite High
Disease 5 28.56 Quite Low
Depressive Disorder 2 11.52 Low Low
Anxiety Disorder 18 5.00 Very Low Very Low Very Low
Paralysis 10 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of clonidine on auditory P300.
Regulation (effect) of P300 associated with clonidine
1) Confidence 0.23 Published 1989 Journal Psychiatry Res Section Title Doc Link 2548222 Disease Relevance 0 Pain Relevance 0.52
P300 latency was not significantly affected.
Neg (not) Regulation (affected) of P300
2) Confidence 0.23 Published 1998 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 9583188 Disease Relevance 0.32 Pain Relevance 0.40
In control experiments with warm water stimulation no significant alterations of P300 or P200 components were found.
Neg (no) Regulation (alterations) of P300
3) Confidence 0.23 Published 1998 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 9583188 Disease Relevance 0.32 Pain Relevance 0.40
This study supports a role for dopamine in the neurobiological modulation of P300 amplitude.
Regulation (modulation) of P300 associated with dopamine
4) Confidence 0.05 Published 1995 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 7535224 Disease Relevance 0.17 Pain Relevance 0.35
P300 amplitude appears to be modulated by multiple neurotransmitter systems, especially dopaminergic, noradrenergic as well as cholinergic and GABAergic.
Regulation (modulated) of P300 associated with neurotransmitter and gabaergic
5) Confidence 0.05 Published 1995 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 7535224 Disease Relevance 0.15 Pain Relevance 0.31
However, in our participant sample the different components of motivation had no obvious effect on the P300 amplitude.
Neg (no) Regulation (effect) of P300
6) Confidence 0.01 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2916671 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

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