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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2d4) oxidoreductase activity (Cyp2d4) endoplasmic reticulum (Cyp2d4)
cellular_component (Cyp2d4) cytoplasm (Cyp2d4)
Cyp2d4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 2 99.46 Very High Very High Very High
tricyclic antidepressant 1 91.28 High High
Angina 1 38.96 Quite Low
tolerance 1 36.04 Quite Low
Dextromethorphan 23 19.80 Low Low
Buprenorphine 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 2 88.84 High High
Hyperuricemia 31 84.48 Quite High
Crystal Associated Disease 54 83.04 Quite High
Hepatotoxicity 4 54.96 Quite High
Coronary Heart Disease 4 51.80 Quite High
Thrombosis Related Under Development 1 41.96 Quite Low
Increased Venous Pressure Under Development 3 41.12 Quite Low
Hypertension 10 40.44 Quite Low
Myocardial Infarction 5 39.88 Quite Low
Cv General 3 Under Development 1 38.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP2D6 is clinically important in the metabolism of up to 25% of all clinical drugs, including ?
Negative_regulation (metabolism) of Gene_expression (important) of CYP2D6
1) Confidence 0.42 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2994065 Disease Relevance 0.14 Pain Relevance 0.05
A small increase in total exposure to desipramine was found suggesting that CYP2D6-mediated metabolism was mildly inhibited, but this was considered clinically insignificant (Khosravan et al 2005b).
Negative_regulation (inhibited) of Gene_expression (metabolism) of CYP2D6-mediated associated with desipramine
2) Confidence 0.19 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.22 Pain Relevance 0.10

General Comments

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