INT261231

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2d4) oxidoreductase activity (Cyp2d4) endoplasmic reticulum (Cyp2d4)
cellular_component (Cyp2d4) cytoplasm (Cyp2d4)
Cyp2d4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 2 99.46 Very High Very High Very High
tricyclic antidepressant 1 91.28 High High
Angina 1 38.96 Quite Low
tolerance 1 36.04 Quite Low
Dextromethorphan 23 19.80 Low Low
Buprenorphine 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 2 88.84 High High
Hyperuricemia 31 84.48 Quite High
Crystal Associated Disease 54 83.04 Quite High
Hepatotoxicity 4 54.96 Quite High
Coronary Heart Disease 4 51.80 Quite High
Thrombosis Related Under Development 1 41.96 Quite Low
Increased Venous Pressure Under Development 3 41.12 Quite Low
Hypertension 10 40.44 Quite Low
Myocardial Infarction 5 39.88 Quite Low
Cv General 3 Under Development 1 38.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP2D6 is clinically important in the metabolism of up to 25% of all clinical drugs, including ?
Negative_regulation (metabolism) of Gene_expression (important) of CYP2D6
1) Confidence 0.42 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2994065 Disease Relevance 0.14 Pain Relevance 0.05
A small increase in total exposure to desipramine was found suggesting that CYP2D6-mediated metabolism was mildly inhibited, but this was considered clinically insignificant (Khosravan et al 2005b).
Negative_regulation (inhibited) of Gene_expression (metabolism) of CYP2D6-mediated associated with desipramine
2) Confidence 0.19 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.22 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox