INT26124

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Context Info
Confidence 0.37
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.25
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ep300) transferase activity, transferring acyl groups (Ep300) DNA binding (Ep300)
transcription factor binding (Ep300) cytoplasm (Ep300)
Ep300 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 6 99.92 Very High Very High Very High
Serotonin 3 99.20 Very High Very High Very High
Pain 13 99.16 Very High Very High Very High
depression 50 98.72 Very High Very High Very High
monoamine 1 97.92 Very High Very High Very High
fluoxetine 4 91.80 High High
antidepressant 4 75.00 Quite High
withdrawal 1 63.64 Quite High
imagery 14 21.16 Low Low
phantom limb 4 8.08 Low Low
Disease Link Frequency Relevance Heat
Pain 13 99.16 Very High Very High Very High
Depression 60 98.72 Very High Very High Very High
Cognitive Disorder 10 75.32 Quite High
Motor Neuron Diseases 68 65.52 Quite High
Disease 10 56.00 Quite High
Phobia 2 45.56 Quite Low
Anxiety Disorder 36 41.28 Quite Low
Obesity 5 17.84 Low Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Paralysis 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P300 was unaffected by clonidine.
Neg (unaffected) Negative_regulation (unaffected) of P300 associated with clonidine
1) Confidence 0.37 Published 1989 Journal Psychiatry Res Section Abstract Doc Link 2548222 Disease Relevance 0 Pain Relevance 0.55
It can be concluded that serotonin selective drugs have a slower onset of P300 amplitude decrease than clomipramine, which has additional effects on monoaminergic and on cholinergic systems.
Negative_regulation (decrease) of P300 associated with serotonin and monoamine
2) Confidence 0.24 Published 1999 Journal Neuropsychobiology Section Abstract Doc Link 10559704 Disease Relevance 0.13 Pain Relevance 0.58
The memory probes elicited an N275 that increased and a P300 that decreased in amplitude during pain.
Negative_regulation (decreased) of P300 associated with pain
3) Confidence 0.23 Published 1997 Journal Psychophysiology Section Abstract Doc Link 9260496 Disease Relevance 0.84 Pain Relevance 0.76
Chromatin immunoprecipitation assays (ChIP) indicate that p160 coactivators and CBP/p300 are recruited to NR target genes rapidly (30 min to 1 h) after ligand binding [Sharma and Fondell, 2002].
Negative_regulation (recruited) of p300
4) Confidence 0.14 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Before starting with SMR or P300 training blocks, physical impairment, QoL, and depression were assessed using questionnaires.
Negative_regulation (blocks) of P300 associated with depression
5) Confidence 0.02 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2916671 Disease Relevance 0.28 Pain Relevance 0.05
After we finished the SMR and P300 study participant D informed us that he no longer wanted to volunteer in BCI studies, because of his tight time schedule.
Negative_regulation (finished) of P300
6) Confidence 0.01 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2916671 Disease Relevance 0 Pain Relevance 0

General Comments

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