INT261242

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.56
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tmed4) transport (Tmed4) endoplasmic reticulum (Tmed4)
signal transducer activity (Tmed4)
Anatomy Link Frequency
central nervous system 1
Tmed4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 66 98.92 Very High Very High Very High
Arthritis 82 98.60 Very High Very High Very High
antagonist 15 98.44 Very High Very High Very High
rheumatoid arthritis 12 96.12 Very High Very High Very High
Inflammation 52 94.04 High High
Central nervous system 3 93.04 High High
cINOD 6 82.76 Quite High
Inflammatory response 4 50.00 Quite Low
Hippocampus 48 43.80 Quite Low
Pain 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 49 98.60 Very High Very High Very High
Rheumatoid Arthritis 12 96.12 Very High Very High Very High
Postmenopausal Osteoporosis 24 95.68 Very High Very High Very High
INFLAMMATION 59 94.04 High High
Arthritis 41 93.60 High High
Apoptosis 5 92.36 High High
Aging 9 82.44 Quite High
Osteoporosis 105 82.08 Quite High
Obesity 399 82.00 Quite High
Endometriosis (extended) 68 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Signal cross-talk between PPAR/RXR and ERs has been reported to occur through competitive binding to ERE [24].
ERs Binding (binding) of
1) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.24 Pain Relevance 0
Similarly, ligand-activated ERs bind to their half-site-containing EREs as homodimers following the recruitment of coactivators.
ERs Binding (bind) of
2) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.12 Pain Relevance 0.04
Estrogen binding to membrane-bound ERs can lead to the activation of G proteins such as Gs and Gq [47], [48].
ERs Binding (bound) of
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664330 Disease Relevance 0.19 Pain Relevance 0.09
Estrogen binding to membrane-bound ERs can lead to the activation of G proteins such as Gs and Gq [47], [48].
ERs Binding (binding) of
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664330 Disease Relevance 0.20 Pain Relevance 0.09
Nonetheless, these sequences contain an AGGTCA half site, which could be recognized by either ERs or PPAR?.
ERs Binding (recognized) of
5) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.07 Pain Relevance 0
While both the ERs bind estrogen as well as other agonists or antagonists (even though with different affinities), they have distinctly different localizations and concentrations in several tissues, including bone (Gustafsson 1999; Bord et al 2001).
ERs Binding (bind) of associated with antagonist and agonist
6) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643104 Disease Relevance 0.53 Pain Relevance 0.10
Moreover, target cells for estrogen action may contain varying concentrations of homodimers of one or both ERs, as well as ER?
ERs Binding (homodimers) of
7) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643104 Disease Relevance 0.73 Pain Relevance 0.08
Several in vitro and in vivo experimental observations demonstrated that bazedoxifene interacts with both ERs inducing receptor transactivation and positively affecting the skeleton and the lipid profile without stimulating the endometrium and the breast or negatively impacting the central nervous system.
ERs Binding (interacts) of in central nervous system associated with central nervous system
8) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643104 Disease Relevance 0.23 Pain Relevance 0.13
In experimental arthritis, most studies report an immune suppressive effect of E2 or EE, which bind both ERs in an agonistic mode [23,24].
ERs Binding (bind) of associated with experimental arthritis and arthritis
9) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.24 Pain Relevance 0.55

General Comments

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