INT261265

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 1.96
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PYGM) small molecule metabolic process (PYGM) transferase activity, transferring glycosyl groups (PYGM)
carbohydrate metabolic process (PYGM) cytoplasm (PYGM)
Anatomy Link Frequency
muscle 5
fat 1
PYGM (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 60 90.44 High High
corticosteroid 18 86.48 High High
methotrexate 16 84.88 Quite High
anesthesia 6 40.00 Quite Low
lidocaine 6 39.04 Quite Low
Etanercept 27 5.00 Very Low Very Low Very Low
Adalimumab 16 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Immobilon 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glycogen Storage Disease 1 99.78 Very High Very High Very High
Disease 26 99.22 Very High Very High Very High
Muscle Disease 3 98.84 Very High Very High Very High
Pulmonary Sarcoidosis 11 97.92 Very High Very High Very High
Sarcoidosis 72 95.28 Very High Very High Very High
Toxicity 5 83.52 Quite High
Repression 6 80.64 Quite High
Granuloma 12 75.32 Quite High
Renal Disease 5 74.16 Quite High
Body Weight 7 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fouchier and colleagues (2004) reported a patient with persistent, refractory symptomatic pulmonary sarcoidosis, complicated by a congenital muscular disease: McArdle’s disease (a glycogen storage disease caused by myophosphorylase deficiency).
Gene_expression (deficiency) of myophosphorylase associated with pulmonary sarcoidosis, glycogen storage disease, muscle disease and disease
1) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643111 Disease Relevance 1.51 Pain Relevance 0.24
After the glycogen depletion, they were given a dinner low in carbohydrates (1%E carbohydrate, 26%E protein, and 73%E fat) to prevent muscle glycogen resynthesis.
Gene_expression (resynthesis) of muscle glycogen in fat
2) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.07 Pain Relevance 0
In addition, the smaller increase in PDHa activity and the smaller decline in PDH dephosphorylation in response to exercise when muscle glycogen was reduced or plasma FFA concentration was elevated initially suggest that each of these factors may modify exercise-induced PDH regulation.
Gene_expression (reduced) of muscle glycogen in muscle
3) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.24 Pain Relevance 0
Of notice is that the low muscle glycogen leg had exercised intensively ?
Gene_expression (leg) of muscle glycogen in muscle
4) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
However, in these studies, plasma FFA and muscle glycogen were manipulated simultaneously, making it impossible to discriminate between the role of muscle glycogen and FFA.
Gene_expression (manipulated) of muscle glycogen in muscle
5) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Thus, the clear differences in exercise-induced muscle glucose-6-phosphate and muscle glucose responses in the normal and the low muscle glycogen muscles in the high FFA trial were not associated with differences in PDH regulation, and despite similar muscle glucose-6-phosphate and muscle glucose levels in the normal glycogen leg in the two trials, PDHa activity was higher in the low FFA trial than in the high FFA trial.
Gene_expression (muscles) of muscle glycogen in muscle
6) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
A relation between muscle glycogen levels and PDHa activity and PDH phosphorylation is in line with our previous finding that further lowering of muscle glycogen during high-intensity exercise was associated with reduced PDHa activity (17).
Gene_expression (levels) of muscle glycogen in muscle
7) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.13 Pain Relevance 0

General Comments

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