INT261273

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.11
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde6a) signal transduction (Pde6a) molecular_function (Pde6a)
cellular_component (Pde6a) biological_process (Pde6a)
Anatomy Link Frequency
retina 3
Pde6a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 13 99.46 Very High Very High Very High
Angina 10 95.44 Very High Very High Very High
Bioavailability 5 82.20 Quite High
backache 14 5.00 Very Low Very Low Very Low
fibrosis 13 5.00 Very Low Very Low Very Low
nud 12 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 13 99.46 Very High Very High Very High
Increased Venous Pressure Under Development 38 99.26 Very High Very High Very High
Cv General 3 Under Development 14 95.44 Very High Very High Very High
Erectile Dysfunction 458 87.20 High High
Heart Rate Under Development 2 79.52 Quite High
Congenital Anomalies 4 64.32 Quite High
Diabetes Mellitus 120 56.32 Quite High
Hepatic Insufficiency 4 53.92 Quite High
Weight Loss 1 48.04 Quite Low
Hypertension 34 47.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flushing, headache, and visual disturbances (PDE-6 inhibition) have also been reported as side effects with use of sildenafil citrate [7].
Negative_regulation (inhibition) of PDE-6 associated with headache and increased venous pressure under development
1) Confidence 0.02 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 0.58 Pain Relevance 0.28
The inhibition of PDE6 explains the side effect of blue vision experienced by some patients with these two drugs, as PDE6 inhibition in the retina causes impairment of blue-green color discrimination (Carson 2007).
Negative_regulation (inhibition) of PDE6 in retina
2) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643112 Disease Relevance 0.06 Pain Relevance 0
The inhibition of PDE6 explains the side effect of blue vision experienced by some patients with these two drugs, as PDE6 inhibition in the retina causes impairment of blue-green color discrimination (Carson 2007).
Negative_regulation (inhibition) of PDE6 in retina
3) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643112 Disease Relevance 0.06 Pain Relevance 0
With respect to PDE5, a 780-fold greater concentration of tadalafil is needed to inhibit PDE6, and a 14-fold greater concentration to inhibit PDE11, an enzyme with unknown physiological function.
Negative_regulation (inhibit) of PDE6
4) Confidence 0.01 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0.27 Pain Relevance 0
Tadalafil is selective for PDE5 and minimally inhibits PDE6 (Angulo et al 2001), which works for visual transduction in the retina.
Negative_regulation (inhibits) of PDE6 in retina
5) Confidence 0.01 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0.13 Pain Relevance 0

General Comments

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