INT261274

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
smooth muscle 2
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 1 98.60 Very High Very High Very High
adenocard 1 76.84 Quite High
Calcium channel 1 31.52 Quite Low
potassium channel 1 30.32 Quite Low
Angina 4 24.24 Low Low
fibrosis 5 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 6 67.28 Quite High
Myocardial Infarction 1 59.76 Quite High
Increased Venous Pressure Under Development 3 55.20 Quite High
Erectile Dysfunction 123 41.12 Quite Low
Cv General 3 Under Development 4 24.24 Low Low
Diabetes Mellitus 30 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 9 5.00 Very Low Very Low Very Low
Lower Urinary Tract Symptoms 8 5.00 Very Low Very Low Very Low
Benign Prostatic Hypertrophy 8 5.00 Very Low Very Low Very Low
Reprotox - General 2 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By inhibiting the breakdown of cGMP, PDE5 inhibitors create increased bioavailability of cGMP, which both facilitates and potentiates the NO-mediated relaxation of erectile smooth muscle with sexual stimulation.
Negative_regulation (inhibiting) of Protein_catabolism (breakdown) of cGMP in smooth muscle associated with bioavailability
1) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643112 Disease Relevance 0.18 Pain Relevance 0.09

General Comments

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