INT261275

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 4 91.20 High High
Bioavailability 1 54.72 Quite High
Serotonin 1 47.16 Quite Low
Dopamine 1 46.60 Quite Low
Neurotransmitter 3 45.32 Quite Low
Central nervous system 1 42.92 Quite Low
adenocard 1 28.28 Quite Low
backache 7 5.00 Very Low Very Low Very Low
nud 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erectile Dysfunction 192 99.22 Very High Very High Very High
Cv General 3 Under Development 6 91.20 High High
Increased Venous Pressure Under Development 12 75.60 Quite High
Myocardial Infarction 2 73.36 Quite High
Diabetes Mellitus 46 72.96 Quite High
Disease 16 70.32 Quite High
Reprotox - General 3 1 55.60 Quite High
Hypoactive Sexual Desire Disorder 4 49.20 Quite Low
Aging 5 22.76 Low Low
Benign Prostatic Hypertrophy 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether the observed changes in the hormonal pattern may be attributed to the increased sexual activity, or directly due to the PDE5 inhibition (eg, NO stimulates hypothalamic gonadotropin-releasing hormone [Kohsaka et al 1999], and inhibits PRL release in rats [Velardez et al 2000]) remains to be determined.
Negative_regulation (inhibits) of Localization (release) of PDE5
1) Confidence 0.31 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0.50 Pain Relevance 0
It was later released in 1998 as the first oral treatment for ED, and this was followed in 2003 by the release of two more PDE5 inhibitors, vardenafil and tadalafil.


Negative_regulation (inhibitors) of Localization (release) of PDE5 associated with erectile dysfunction
2) Confidence 0.22 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643112 Disease Relevance 0.61 Pain Relevance 0.18

General Comments

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