INT2613

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 8.20
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 24
thyroid 2
sympathetic 2
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 18 99.98 Very High Very High Very High
fluoxetine 10 99.84 Very High Very High Very High
epidural 4 99.84 Very High Very High Very High
Versed 6 99.56 Very High Very High Very High
analgesia 5 99.48 Very High Very High Very High
Serotonin 5 99.34 Very High Very High Very High
adenocard 12 99.30 Very High Very High Very High
beta blocker 3 98.76 Very High Very High Very High
anesthesia 9 98.00 Very High Very High Very High
narcan 9 97.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 38 100.00 Very High Very High Very High
Hypopituitarism 1 99.96 Very High Very High Very High
Bordatella Infection 4 98.80 Very High Very High Very High
Insulin Resistance 16 96.84 Very High Very High Very High
Hypotension 2 96.28 Very High Very High Very High
Hypertension 16 95.96 Very High Very High Very High
Syndrome 4 95.96 Very High Very High Very High
Disorder Of Lipid Metabolism 19 93.56 High High
Hyperlipidemia 2 91.88 High High
Diabetes Mellitus 3 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with either of the blockers of serotonin uptake, fluoxetine or indalpine blocked the increase in plasma renin activity induced by fenfluramine at 30 min, but did not affect the decrease at 4 hr after injection.
Negative_regulation (blocked) of Positive_regulation (increase) of renin in plasma associated with serotonin and fluoxetine
1) Confidence 0.59 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3160963 Disease Relevance 0 Pain Relevance 0.29
During an investigation of the role of the mediobasal hypothalamus in the regulation of renin secretion from the kidneys, we found that lesions of the ventromedial nuclei prevented the increase in plasma renin activity produced by p-chloroamphetamine.
Negative_regulation (prevented) of Positive_regulation (increase) of plasma renin in plasma
2) Confidence 0.51 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3041306 Disease Relevance 0 Pain Relevance 0.08
Simultaneous removals of submandibular glands but not of adrenal glands completely prevented the postnephrectomy increases of plasma inactive renin.
Negative_regulation (prevented) of Positive_regulation (increases) of renin in plasma
3) Confidence 0.51 Published 1987 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 3322883 Disease Relevance 0 Pain Relevance 0
Propranolol partially blocked the increase in plasma renin concentration produced by anesthetics.
Negative_regulation (blocked) of Positive_regulation (increase) of plasma renin in plasma
4) Confidence 0.50 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3894036 Disease Relevance 0.27 Pain Relevance 0.17
The increases in plasma renin activity were blocked by propranolol.
Negative_regulation (blocked) of Positive_regulation (increases) of plasma renin in plasma
5) Confidence 0.43 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.24
Triphasics entail a reduction in the levels of estradiol and testosterone and a slight increase of plasma renin activity but no modification in plasma aldosterone.
Negative_regulation (reduction) of Positive_regulation (increase) of renin in plasma
6) Confidence 0.42 Published 1985 Journal Contracept Fertil Sex (Paris) Section Abstract Doc Link 12280209 Disease Relevance 0.36 Pain Relevance 0.07
Administration of the beta-blocker propranolol (1 mg/kg i.p.) inhibited, but did not completely block, stress-induced rise in plasma-renin activity and had no effect on stress-induced prolactin secretion.
Negative_regulation (block) of Positive_regulation (rise) of plasma-renin in plasma associated with stress and beta blocker
7) Confidence 0.41 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994844 Disease Relevance 0.99 Pain Relevance 0.32
The administration of the antianxiety drugs chlordiazepoxide (10 mg/kg i.p.) or midazolam (0.125-2 mg/kg i.p.) blocked the stress-induced increase in prolactin levels but not the stress-induced rise in plasma renin activity.
Negative_regulation (blocked) of Positive_regulation (rise) of plasma renin in plasma associated with stress and versed
8) Confidence 0.40 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994844 Disease Relevance 1.00 Pain Relevance 0.30
The opiate antagonist naloxone (0.1-10 mg/kg i.p.) and the acetylcholinesterase inhibitor diisopropyl fluorophosphate (0.5 mg/kg i.p.) did not block stress-induced renin or prolactin secretion.
Negative_regulation (block) of Positive_regulation (stress-induced) of renin associated with stress, antagonist, narcan and opiate
9) Confidence 0.40 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994844 Disease Relevance 0.94 Pain Relevance 0.32
The normal stress-induced increase in plasma renin activity and aldosterone was inhibited by epidural analgesia.
Negative_regulation (inhibited) of Positive_regulation (increase) of renin in plasma associated with stress, epidural and analgesia
10) Confidence 0.40 Published 1979 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 484183 Disease Relevance 0.19 Pain Relevance 0.55
These results indicate that clonidine reduces stimulated renin by a central mechanism that is dependent upon the integrity of the sympathetic innervation of the kidney.
Negative_regulation (reduces) of Positive_regulation (stimulated) of renin in sympathetic associated with clonidine
11) Confidence 0.37 Published 1980 Journal Hypertension Section Abstract Doc Link 6991409 Disease Relevance 0.17 Pain Relevance 0.77
Suppression of stimulated plasma renin by clonidine in the dog.
Negative_regulation (Suppression) of Positive_regulation (stimulated) of renin in plasma associated with clonidine
12) Confidence 0.37 Published 1980 Journal Hypertension Section Title Doc Link 6991409 Disease Relevance 0.15 Pain Relevance 0.73
However, the stress-induced increase in plasma levels of ACTH, corticosterone, oxytocin, prolactin and renin were not inhibited by fluoxetine treatment.
Negative_regulation (inhibited) of Positive_regulation (increase) of renin in plasma associated with stress and fluoxetine
13) Confidence 0.36 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650130 Disease Relevance 1.15 Pain Relevance 1.01
However, an array of other endocrine alterations, like hypopituitarism, decreased thyroid and sex hormones, increased Glucocorticoids, the activation of Renin Angiotensin Aldosterone System (RAAS) and changes in adipokines are shown [19].
Negative_regulation (decreased) of Positive_regulation (activation) of Renin in thyroid associated with hypopituitarism
14) Confidence 0.23 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2262079 Disease Relevance 2.90 Pain Relevance 0.21
Captopril antihypertensive effect and captopril-induced plasma renin increase were almost totally abolished by a short-term administration of indomethacin (50 mg t.i.d.).
Negative_regulation (abolished) of Positive_regulation (increase) of renin in plasma
15) Confidence 0.05 Published 1984 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6432714 Disease Relevance 0.10 Pain Relevance 0.08
The effect of exogenous Ang II on [3H]adenosine release was greatly enhanced when activation of the endogenous renin-angiotensin system was prevented with prior nephrectomy.
Negative_regulation (prevented) of Positive_regulation (activation) of renin-angiotensin associated with adenocard
16) Confidence 0.04 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1696651 Disease Relevance 0 Pain Relevance 0.49

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