INT261349

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
thyroid 1
Syn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 2 63.52 Quite High
Dopamine 35 62.96 Quite High
cerebral cortex 1 16.64 Low Low
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 220 99.72 Very High Very High Very High
Congenital Anomalies 44 84.80 Quite High
Psychosis 7 30.08 Quite Low
Neurodegenerative Disease 6 10.64 Low Low
Disease 26 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low
Autism 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pancreatic islet cells, low-dose BPA activates CREB through a nonclassical ER-related mechanism.254 There is some controversy as to whether and how BPA influences mitogen-activated protein (MAP) although CREB may be a downstream target of MAP.253 One study found only the brominated form of BPA, tetrabromobisphenol A (TBBPA), influences MAPKs in a cell-specific and dose-dependent manner.255 Another study found that in cultured rat hypothalamic cells, BPA increases both MAP2 and synapsin I.130 Synapsin I has not been associated with schizophrenia, and generally synapsin reductions instead of increases are found in schizophrenia.256 However, reductions in synapsin are associated with developmental thyroid insufficiency.
Negative_regulation (reductions) of synapsin in thyroid associated with schizophrenia
1) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.72 Pain Relevance 0.06

General Comments

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