INT261365

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.96
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Tgs1) nucleus (Tgs1) cytoplasm (Tgs1)
Anatomy Link Frequency
Thyroid 1
Tgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 3 95.02 Very High Very High Very High
tolerance 11 94.16 High High
Dopamine 35 89.22 High High
Hippocampus 5 24.40 Low Low
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psychosis 7 99.76 Very High Very High Very High
Insulin Resistance 3 99.76 Very High Very High Very High
Autism 8 99.32 Very High Very High Very High
Schizophrenia 220 98.84 Very High Very High Very High
Thyroid Disease 6 98.84 Very High Very High Very High
Impaired Glucose Tolerance 12 94.16 High High
Atherosclerosis 5 79.20 Quite High
Stress 18 74.36 Quite High
Disorder Of Lipid Metabolism 23 73.20 Quite High
Congenital Anomalies 44 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are reports on the association of elevated serum TGs with insulin resistance.
TGs Binding (association) of associated with insulin resistance
1) Confidence 0.04 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937313 Disease Relevance 0.85 Pain Relevance 0.09
RARalplha is increased 2-fold in schizophrenia,228 and retinoid X receptor gamma1 is known to modulate DA-mediated processes.229 There is also evidence of retinoid and thyroid hormone gene interactions with the environment in schizophrenia.230 Thyroid hormones regulate both neurogranin and retinoids, and thyroid hormones also regulate neuronal calmodulin-Ca(2+) downstream of the NMDA receptor.231 In schizophrenia, the prefrontal cortex has reduced neurogranin in area 9 and 32,232 and there is an association of the neurogranin gene in males with schizophrenia.231 The schizophrenia candidate gene, HOPA, codes a member of thyroid receptor coactivator protein (TRAP) that is associated with psychosis, autism, and hypothyroidism.233–235 The association of hypothyroidism induced by PCB and its effect on ChAt and potential relationship with schizophrenia was discussed above.
coactivator protein Binding (associated) of in Thyroid associated with dopamine, autism, psychosis, nmda receptor, thyroid disease and schizophrenia
2) Confidence 0.00 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.11 Pain Relevance 0.09

General Comments

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