INT261368

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.33
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ncs1) Golgi apparatus (Ncs1) plasma membrane (Ncs1)
cytoplasm (Ncs1)
Anatomy Link Frequency
neurons 1
Ncs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 35 82.96 Quite High
cerebral cortex 1 51.52 Quite High
nMDA receptor 3 30.32 Quite Low
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 220 99.74 Very High Very High Very High
Congenital Anomalies 44 97.08 Very High Very High Very High
Manic Depressive Disorder 5 81.12 Quite High
Huntington's Chorea 1 80.12 Quite High
Neurodegenerative Disease 6 79.36 Quite High
Disease 26 79.20 Quite High
Cognitive Disorder 5 27.28 Quite Low
Stress 14 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In schizophrenia, Ca2+ abnormalities may be the link through which elevations of calcyon and neuronal calcium sensor-1 protein influence the development of schizophrenia.272–274 The calcium sensor protein caldendrin, with an important role in brain Ca2+ signaling, is reduced in cortical neurons in chronic schizophrenia.275,276
Negative_regulation (reduced) of calcium sensor protein in neurons associated with congenital anomalies and schizophrenia
1) Confidence 0.03 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.33 Pain Relevance 0.07

General Comments

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