INT261371

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.18
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) oxidoreductase activity (Nsdhl) endoplasmic reticulum (Nsdhl)
cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
glutamatergic neurons 2
Nsdhl (Mus musculus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 35 93.26 High High
Serotonin 2 41.60 Quite Low
Hippocampus 5 31.92 Quite Low
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psychosis 7 98.78 Very High Very High Very High
Schizophrenia 220 97.52 Very High Very High Very High
Neurodegenerative Disease 6 78.12 Quite High
Congenital Anomalies 44 74.08 Quite High
Parkinson's Disease 1 68.76 Quite High
Dementia 2 68.08 Quite High
Brain Disease 2 64.40 Quite High
Death 5 62.76 Quite High
Stress 14 60.48 Quite High
Thyroid Disease 6 38.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As mentioned previously, BDNF and DA neurotransmission appear linked in schizophrenia.181 Increased BDNF associated with hyperactive glutamatergic neurons has been found in cerebellar granule cells in schizophrenia.244 Another study of schizophrenia found reduced plasma levels of BDNF in first-episode psychosis compared with normal.245 In mouse cerebellar granule cells, BPA decreases induction of both BDNF and c-fos mRNA.246 These results are difficult to interpret as induction of c-fos may be altered in similar directions by amphetamine, PCP, and antipsychotic treatment depending on brain region, dose, timing, and environment.247–250

cAMP-Responsive Element-Binding Protein and Mitogen-Activated Protein.

BPA Negative_regulation (decreases) of Positive_regulation (induction) of BDNF in glutamatergic neurons associated with dopamine, psychosis and schizophrenia
1) Confidence 0.06 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.18 Pain Relevance 0.09

General Comments

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