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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Nsdhl) endoplasmic reticulum (Nsdhl) cytoplasm (Nrgn)
Anatomy Link Frequency
hippocampus 2
Nsdhl (Mus musculus)
Nrgn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 97.00 Very High Very High Very High
nMDA receptor 3 55.16 Quite High
Dopamine 35 43.56 Quite Low
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 6 93.92 High High
Schizophrenia 220 73.68 Quite High
Autism 8 67.84 Quite High
Psychosis 7 67.52 Quite High
Neurodegenerative Disease 6 52.88 Quite High
Congenital Anomalies 44 50.00 Quite Low
Stress 14 36.48 Quite Low
Death 5 31.84 Quite Low
Brain Disease 2 29.36 Quite Low
Dementia 2 21.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BPA increases RARalpha and retinoid X receptor alpha mRNA expression in the cerebrum and cerebellum of male and female mouse embryos.76 In Xenopus (tadpole) tail culture, BPA upregulates thyroid hormone receptor alpha and beta and downregulates RXRgamma.236 When rats are fed BPA during pregnancy and lactation, total thyroid hormone T4 increases in the dentate gyrus of offspring without effect on thyroid-stimulating hormone.237 These changes are accompanied by upregulation of the thyroid hormone-response gene that encodes RC3/neurogranin.237 Another study of perinatal BPA exposure found RC3/neurogranin expression was unchanged by BPA administration, but steroid receptor coactivator-1 was upregulated in the hippocampus of male pups.238 In that study, exposed dams developed temporary hypothyroidism, but male pups developed transient hyperthyroidism followed by hypothyroidism.
BPA Positive_regulation (unchanged) of Gene_expression (expression) of neurogranin in hippocampus associated with thyroid disease and hippocampus
1) Confidence 0.06 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.86 Pain Relevance 0.08

General Comments

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