INT261384

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.43
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Nsdhl) endoplasmic reticulum (Nsdhl) plasma membrane (Mbp)
Anatomy Link Frequency
Astrocytes 2
Nsdhl (Mus musculus)
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 1 77.32 Quite High
cytokine 2 74.24 Quite High
Glutamate 3 65.28 Quite High
Hippocampus 5 63.24 Quite High
Dopamine 35 38.16 Quite Low
midbrain 6 30.24 Quite Low
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 220 99.90 Very High Very High Very High
Congenital Anomalies 44 98.98 Very High Very High Very High
Leukemia 1 90.80 High High
Disease 26 69.04 Quite High
Autoimmune Disease 4 67.60 Quite High
Toxicity 4 66.64 Quite High
Alzheimer's Dementia 1 65.76 Quite High
Attention Deficit Hyperactivity Disorder 10 45.20 Quite Low
Autism 8 44.88 Quite Low
Apoptosis 12 27.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abnormalities of oligodendrocyte survival and differentiation as well as abnormal expressions of oligodendrocyte and myelin genes are reported in schizophrenia.114,115 Reductions in oligodendrocyte numbers and abnormalities of myelin sheaths also occur in schizophrenia.116 BPA inhibits differentiation of oligodendrocyte precursor cells in rodents117 and impairs the expression of myelin basic protein.117

Astrocytes.

BPA Negative_regulation (impairs) of Gene_expression (expression) of myelin basic protein in Astrocytes associated with congenital anomalies and schizophrenia
1) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.43 Pain Relevance 0.14

General Comments

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