INT261387

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Casp3) endoplasmic reticulum (Nsdhl) intracellular (Casp3)
cytoplasm (Casp3) cytosol (Casp3) peptidase activity (Casp3)
Anatomy Link Frequency
brain 1
Nsdhl (Mus musculus)
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 3 96.14 Very High Very High Very High
Locus ceruleus 10 66.08 Quite High
midbrain 6 14.40 Low Low
Dopamine 35 5.00 Very Low Very Low Very Low
gABA 16 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 12 99.44 Very High Very High Very High
Death 5 98.36 Very High Very High Very High
Neurodegenerative Disease 6 95.78 Very High Very High Very High
Schizophrenia 220 82.64 Quite High
Congenital Anomalies 44 66.76 Quite High
Suicidal Behaviour 2 39.96 Quite Low
Disease 26 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low
Autism 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased neurogenesis in a rat ketamine model of schizophrenia100 parallels increased cortical and hippocampal neuronal growth from BPA exposure that affects caspase-3, a protein involved in the apoptosis process, in rat brains.101 BPA interferes with normal brain development by inhibiting caspase-3 thus preventing desirable neuronal cell death.
BPA Negative_regulation (inhibiting) of caspase-3 in brain associated with ketamine, apoptosis, neurodegenerative disease and death
1) Confidence 0.03 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.08 Pain Relevance 0.19

General Comments

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