INT261389

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Esr2) endoplasmic reticulum (Nsdhl) enzyme binding (Esr2)
DNA binding (Esr2) cytoplasm (Esr2) oxidoreductase activity (Nsdhl)
Anatomy Link Frequency
pituitary 2
Nsdhl (Mus musculus)
Esr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 10 82.96 Quite High
amygdala 4 76.24 Quite High
Glutamate 6 34.76 Quite Low
antagonist 4 22.56 Low Low
Dopamine 70 5.00 Very Low Very Low Very Low
gABA 32 5.00 Very Low Very Low Very Low
Locus ceruleus 20 5.00 Very Low Very Low Very Low
midbrain 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Somatostatin 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Galactorrhea 8 96.32 Very High Very High Very High
Schizophrenia 440 89.16 High High
Urological Neuroanatomy 8 76.88 Quite High
Congenital Anomalies 88 71.52 Quite High
Disease 52 38.64 Quite Low
Toxicity 8 35.12 Quite Low
Stress 28 7.68 Low Low
Apoptosis 24 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 20 5.00 Very Low Very Low Very Low
Autism 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neonatal and pubertal exposure to BPA alters or disrupts hypothalamic ERalpha transcription in a sexually dimorphic manner.82,85 Neonatal BPA exposure of female animals causes increases of ERalpha but not ERbeta in the medial basal hypothalamus but not in the anterior pituitary.84 In males, BPA increases both ERalplha and ERbeta in the pituitary but not in the hypothalamus.84 BPA treatment causes delayed and sustained hyperprolactinemia in both sexes of offspring,84 which could explain some portion of these changes in ERs.
BPA Neg (not) Positive_regulation (increases) of ERbeta in pituitary associated with galactorrhea
1) Confidence 0.06 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.53 Pain Relevance 0.12
Neonatal and pubertal exposure to BPA alters or disrupts hypothalamic ERalpha transcription in a sexually dimorphic manner.82,85 Neonatal BPA exposure of female animals causes increases of ERalpha but not ERbeta in the medial basal hypothalamus but not in the anterior pituitary.84 In males, BPA increases both ERalplha and ERbeta in the pituitary but not in the hypothalamus.84 BPA treatment causes delayed and sustained hyperprolactinemia in both sexes of offspring,84 which could explain some portion of these changes in ERs.
BPA Neg (not) Positive_regulation (increases) of ERbeta in pituitary associated with galactorrhea
2) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.51 Pain Relevance 0.11

General Comments

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