INT261391

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nsdhl, P4hb) isomerase activity (P4hb) oxidoreductase activity (Nsdhl)
plasma membrane (P4hb)
Anatomy Link Frequency
neuronal 1
Nsdhl (Mus musculus)
P4hb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 35 72.24 Quite High
Hippocampus 5 62.96 Quite High
nMDA receptor 3 12.96 Low Low
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 1 99.90 Very High Very High Very High
Dementia 2 99.56 Very High Very High Very High
Neurodegenerative Disease 6 98.52 Very High Very High Very High
Brain Disease 2 97.72 Very High Very High Very High
Death 5 96.90 Very High Very High Very High
Stress 14 95.76 Very High Very High Very High
Schizophrenia 220 86.00 High High
Thyroid Disease 6 69.28 Quite High
Congenital Anomalies 44 50.00 Quite Low
Psychosis 7 44.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDI provides neuroprotection by facilitating protein folding and preventing misfolding.241 PDI is believed to prevent nitrosative stress that leads to protein misfolding and neuronal cell death that causes degenerative brain disorders.241 Several neurodegenerative disorders are linked to protein misfolding including dementia with Lewy bodies.242 BPA binds to PDI and inhibits its activity.243 The deactivation of PDI may be responsible for various effects of BPA,243 and one could speculate that inhibition of PDI by BPA would increase the risk of neurodegenerative disorders.


BPA Binding (binds) of PDI in neuronal associated with parkinson's disease, stress, dementia, brain disease, neurodegenerative disease and death
1) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.30 Pain Relevance 0.10

General Comments

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