INT261442

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
DA neurons 2
Drd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 62 98.96 Very High Very High Very High
Substantia nigra 9 95.56 Very High Very High Very High
Glutamate 2 41.84 Quite Low
Nucleus accumbens 17 5.00 Very Low Very Low Very Low
agonist 14 5.00 Very Low Very Low Very Low
Ventral tegmentum 13 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 99.74 Very High Very High Very High
Dyskinesias 1 92.04 High High
Stress 2 86.96 High High
Injury 4 76.80 Quite High
Drug Induced Neurotoxicity 2 67.68 Quite High
Toxicity 1 42.20 Quite Low
Neurodegenerative Disease 1 14.88 Low Low
Nerve Degeneration 1 13.52 Low Low
Schizophrenia 25 5.00 Very Low Very Low Very Low
Hypertension 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, there is a considerable need for new drugs aimed at relieving the motor symptoms associated with PD by directly depressing D3 receptor expression and protecting surviving DA neurons against, or slowing down the progression of, neuronal degeneration in the SN [24, 54].
Negative_regulation (depressing) of Gene_expression (expression) of D3 receptor in DA neurons associated with dopamine, substantia nigra and disease
1) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.70 Pain Relevance 0.35

General Comments

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