INT261452

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptgdr) cytoplasm (Hrasls) signal transducer activity (Ptgdr)
Anatomy Link Frequency
neurons 1
Ptgdr (Rattus norvegicus)
Hrasls (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 3 83.96 Quite High
agonist 14 80.80 Quite High
Dopamine 62 76.64 Quite High
Substantia nigra 9 58.16 Quite High
Nucleus accumbens 17 19.80 Low Low
Ventral tegmentum 13 17.48 Low Low
Central nervous system 7 8.84 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
noradrenaline 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 3 83.96 Quite High
Schizophrenia 25 66.96 Quite High
Cognitive Disorder 3 24.12 Low Low
Disease 28 15.20 Low Low
Hypertension 9 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Natriuresis 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using both immunoprecipitation and immunohistochemistry methods, Lee et al. demonstrated that D1 and D2 receptors are co-expressed and co-localized within striatal neurons and that these two receptors are part of the same heteromeric protein complex and a phospholipase C-mediated calcium pathway that is only activated by both D1 and D2 receptor co-activation [47].
D2 receptor Positive_regulation (activated) of phospholipase in neurons
1) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.30 Pain Relevance 0.33

General Comments

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