INT261459

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) extracellular space (Sftpd)
oxidoreductase activity (Ldha) extracellular region (Sftpd) cytoplasm (Ldha)
Anatomy Link Frequency
neurons 1
Sftpd (Rattus norvegicus)
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 4 99.40 Very High Very High Very High
Calcium channel 1 70.04 Quite High
noradrenaline 2 45.24 Quite Low
Dopamine 62 39.00 Quite Low
agonist 14 23.64 Low Low
Central nervous system 7 12.40 Low Low
antagonist 8 11.96 Low Low
Nucleus accumbens 17 5.00 Very Low Very Low Very Low
Ventral tegmentum 13 5.00 Very Low Very Low Very Low
Substantia nigra 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 99.40 Very High Very High Very High
Injury 4 99.28 Very High Very High Very High
Hypoxia 1 95.84 Very High Very High Very High
Drug Induced Neurotoxicity 2 52.96 Quite High
Hypertension 9 8.40 Low Low
Disease 28 5.00 Very Low Very Low Very Low
Schizophrenia 25 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, SPD reduced lactate dehydrogenase, an indicator of injury, from neurons following ischemia, suggesting that SPD protects neurons against hypoxia-induced injury, which has been further confirmed by histological studies in striatal neurons [66].
SPD Negative_regulation (reduced) of lactate dehydrogenase in neurons associated with hypoxia, ischemia and injury
1) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.63 Pain Relevance 0.18

General Comments

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