INT261461

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akr1d1) extracellular space (Sftpd) extracellular region (Sftpd)
oxidoreductase activity (Akr1d1) cytoplasm (Akr1d1)
Anatomy Link Frequency
DA neurons 2
Akr1d1 (Rattus norvegicus)
Sftpd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 62 100.00 Very High Very High Very High
Nucleus accumbens 17 100.00 Very High Very High Very High
agonist 14 92.88 High High
antagonist 8 87.00 High High
Ventral tegmentum 13 84.52 Quite High
Pyramidal cell 1 78.00 Quite High
Glutamate 2 73.36 Quite High
Central nervous system 7 24.24 Low Low
Substantia nigra 9 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 5.00 Very Low Very Low Very Low
Schizophrenia 25 5.00 Very Low Very Low Very Low
Hypertension 9 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Natriuresis 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The D1 agonistic effect of SPD on spontaneous firing, however, is not observed in the NAc using direct microiontophoresis [88], suggesting that the D1 agonistic effect of SPD (i.v.) on NAc DA neurons is probably mediated by some indirect action in the mesocorticolimbic system.
Positive_regulation (mediated) of D1 Regulation (effect) of SPD in DA neurons associated with nucleus accumbens and dopamine
1) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0 Pain Relevance 0.86

General Comments

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