INT261463

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.13
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sftpd) extracellular region (Sftpd) endoplasmic reticulum (Drd1a)
plasma membrane (Drd1a) nucleus (Drd1a) intracellular (Drd1a)
Drd1a (Rattus norvegicus)
Sftpd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 24 97.96 Very High Very High Very High
agonist 42 95.32 Very High Very High Very High
Dopamine 186 94.88 High High
Nucleus accumbens 51 72.96 Quite High
Ventral tegmentum 39 72.24 Quite High
Substantia nigra 27 53.68 Quite High
Central nervous system 21 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
noradrenaline 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 84 82.92 Quite High
Schizophrenia 75 37.60 Quite Low
Hypertension 27 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 12 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 9 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Natriuresis 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, binding experiments showed that SPD binds to the D1 receptor with high affinity (Ki = 13 nM, [76]), but exhibits much lower affinity for other receptors [35, 84].
D1 receptor Binding (binds) of SPD
1) Confidence 0.12 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0 Pain Relevance 0.25
Moreover, in vitro radioligand binding assay demonstrated that SPD was able to bind to the D1 receptor at two sites, a high-affinity site (Ki = 3.9 nM) and a low-affinity site (Ki = 126 nM), using calf striatal membrane preparations [16].
D1 receptor Binding (bind) of SPD
2) Confidence 0.11 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.08 Pain Relevance 0.57
In 6-OHDA-induced lesioned rats, unlike its D1 receptor agonistic effect, SPD induced animal rotation towards the intact side by blocking D2 receptors [15, 34, 37, 86].
D1 receptor Binding (effect) of SPD
3) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.05 Pain Relevance 0.53

General Comments

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