INT261483

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.37
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ephb1, Trpv1) cytosol (Trpv1) endosome (Ephb1)
signal transduction (Ephb1) lipid metabolic process (Trpv1) cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 2
Ephb1 (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Stimulus evoked pain 4 99.88 Very High Very High Very High
Neuropeptide 2 92.32 High High
Sciatic nerve 2 88.60 High High
Neuropathic pain 16 86.48 High High
Inflammation 40 83.32 Quite High
Nerve growth factor 14 76.48 Quite High
Central nervous system 6 74.68 Quite High
Pain 48 64.96 Quite High
Spinal cord 44 57.80 Quite High
Opioid 2 57.04 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 6 99.88 Very High Very High Very High
Pain 50 99.20 Very High Very High Very High
Neuropathic Pain 32 86.48 High High
INFLAMMATION 32 83.32 Quite High
Nociception 16 63.44 Quite High
Attention Deficit Hyperactivity Disorder 4 51.88 Quite High
Spinal Injuries 4 50.68 Quite High
Injury 12 39.32 Quite Low
Spinal Cord Injury 16 34.96 Quite Low
Hyperalgesia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK activation in DRG neurons may also contribute to altered heat sensitivity by interacting with the transient receptor potential vanilloid receptor-1 (TRPV1), as demonstrated by Zhuang et al. (2004) [118].
ERK Binding (interacting) of vanilloid receptor-1 in neurons
1) Confidence 0.39 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.68 Pain Relevance 0.68
ERK activation in DRG neurons may also contribute to altered heat sensitivity by interacting with the transient receptor potential vanilloid receptor-1 (TRPV1), as demonstrated by Zhuang et al. (2004) [118].
ERK Binding (interacting) of TRPV1 in neurons
2) Confidence 0.26 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.68 Pain Relevance 0.69

General Comments

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