INT261499

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) small molecule metabolic process (CBS) lyase activity (CBS)
enzyme binding (CBS) response to stress (CNR1) signal transducer activity (CNR1)
CBS (Homo sapiens)
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 12 99.40 Very High Very High Very High
Dopamine 83 96.36 Very High Very High Very High
ischemia 5 93.00 High High
Endocannabinoid 14 50.00 Quite Low
midbrain 7 50.00 Quite Low
Cannabinoid 30 27.40 Quite Low
Ventral tegmentum 16 5.00 Very Low Very Low Very Low
addiction 15 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
GABAergic 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 5 93.00 High High
Neurological Disease 3 70.16 Quite High
Stress 5 65.64 Quite High
Disease 31 61.60 Quite High
Movement Disorders 3 60.56 Quite High
Parkinson's Disease 3 52.96 Quite High
Death 4 46.00 Quite Low
Neurodegenerative Disease 4 30.04 Quite Low
Injury 6 15.08 Low Low
Epilepsy 1 5.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current hypothesis posits that activation of CB1 receptors by eCBs might depress glutamate release in the ischemic tissue, and consequently decrease Ca2+ entry and the excitotoxic damage.
eCBs Positive_regulation (activation) of CB1 associated with glutamate
1) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0.48 Pain Relevance 0.35

General Comments

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