INT261509

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (ST13) protein folding (ST13) cytosol (ST13)
protein binding, bridging (ST13) protein complex (ST13) cytoplasm (ST13)
Anatomy Link Frequency
neurons 1
ST13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 269 100.00 Very High Very High Very High
GABAergic 38 100.00 Very High Very High Very High
Ventral tegmentum 33 100.00 Very High Very High Very High
agonist 46 98.48 Very High Very High Very High
Neurotransmitter 7 93.72 High High
dopamine receptor 29 89.28 High High
Glutamate 28 84.48 Quite High
antagonist 13 84.48 Quite High
Substantia nigra 18 84.04 Quite High
gABA 34 81.28 Quite High
Disease Link Frequency Relevance Heat
Disease 84 95.40 Very High Very High Very High
Parkinson's Disease 27 94.72 High High
Injury 12 90.72 High High
Stress 10 78.00 Quite High
Death 8 74.04 Quite High
Neurological Disease 6 69.44 Quite High
Anxiety Disorder 5 64.68 Quite High
Aging 2 53.32 Quite High
Movement Disorders 8 49.16 Quite Low
Drug Dependence 22 30.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But if this is the case, the most likely scenario is that SNc DA cells would release eCBs to dampen the hyperactivated corticostriatal glutamatergic transmission, a feature of experimental models of PD [19, 20, 23, 183].
Localization (release) of SNc associated with dopamine and disease
1) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0.93 Pain Relevance 0.33
Depletion of dopamine release from SNc neurons through local intranigral administration of the VMAT2 inhibitor tetrabenazine was shown to impair motor performance in rats without altering striatal dopamine release (Andersson et al., 2006).



Localization (release) of SNc in neurons associated with dopamine
2) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.43 Pain Relevance 0.46
Consistently, in vitro electrophysiological experiments from independent laboratories have provided evidence of CB1 receptor localization on glutamatergic and GABAergic axon terminals in the VTA and SNc.
Localization (localization) of SNc associated with ventral tegmentum and gabaergic
3) Confidence 0.00 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0 Pain Relevance 0.97

General Comments

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