INT261579

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.69 Pain Relevance 0.18

mitochondrion (CYBB) extracellular space (Serpinc1) oxidoreductase activity (CYBB) extracellular region (Serpinc1) plasma membrane (CYBB) cytoplasm (CYBB)

Anatomy Link Frequency dopaminergic neurons 2 Serpinc1 (Mus musculus) CYBB (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 13 100.00 Spinal cord 1 87.24 Inflammation 93 62.08 Nicotine 13 13.76 cINOD 15 5.00 Inflammatory response 9 5.00 Somatostatin 9 5.00 agonist 8 5.00 diclofenac 4 5.00 Hippocampus 4 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 3 100.00 Mycobacterium Infection 4 91.28 Neurodegenerative Disease 3 90.24 Frailty 1 87.52 Disease 131 86.16 Motor Neuron Diseases 1 85.96 Targeted Disruption 13 84.40 Disease Progression 1 83.76 Animal Disease Models 1 80.56 Cognitive Disorder 9 66.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In three different PD animal models of dopaminergic cell loss, induced by thrombin [28], paraquat [136], or MPTP [186], administration of minocycline inhibited microglia activation, and reduced free radical production by inhibiting the microglial NADPH oxidase respiratory, iNOS and cytokine production, which resulted in significant reduction in the loss of dopaminergic neurons.

thrombin Negative_regulation (inhibiting) of Gene_expression (production) of microglial NADPH oxidase in dopaminergic neurons associated with parkinson's disease and cytokine

1) Confidence 0.00 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 1.69 Pain Relevance 0.18

General Comments

This test has worked.