INT261579

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.69
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) extracellular space (Serpinc1) oxidoreductase activity (CYBB)
extracellular region (Serpinc1) plasma membrane (CYBB) cytoplasm (CYBB)
Anatomy Link Frequency
dopaminergic neurons 2
Serpinc1 (Mus musculus)
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 100.00 Very High Very High Very High
Spinal cord 1 87.24 High High
Inflammation 93 62.08 Quite High
Nicotine 13 13.76 Low Low
cINOD 15 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Somatostatin 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
diclofenac 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 3 100.00 Very High Very High Very High
Mycobacterium Infection 4 91.28 High High
Neurodegenerative Disease 3 90.24 High High
Frailty 1 87.52 High High
Disease 131 86.16 High High
Motor Neuron Diseases 1 85.96 High High
Targeted Disruption 13 84.40 Quite High
Disease Progression 1 83.76 Quite High
Animal Disease Models 1 80.56 Quite High
Cognitive Disorder 9 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In three different PD animal models of dopaminergic cell loss, induced by thrombin [28], paraquat [136], or MPTP [186], administration of minocycline inhibited microglia activation, and reduced free radical production by inhibiting the microglial NADPH oxidase respiratory, iNOS and cytokine production, which resulted in significant reduction in the loss of dopaminergic neurons.


thrombin Negative_regulation (inhibiting) of Gene_expression (production) of microglial NADPH oxidase in dopaminergic neurons associated with parkinson's disease and cytokine
1) Confidence 0.00 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 1.69 Pain Relevance 0.18

General Comments

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