INT261598

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.56
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
Lung 4
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 91 100.00 Very High Very High Very High
Inflammatory mediators 3 99.66 Very High Very High Very High
Substantia nigra 111 82.00 Quite High
cytokine 52 77.80 Quite High
dopaminergic neurodegeneration 15 50.00 Quite Low
Dopamine 18 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
midbrain 9 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 100 100.00 Very High Very High Very High
Adhesions 18 100.00 Very High Very High Very High
Hypoxia 174 99.96 Very High Very High Very High
Right Ventricular Hypertrophy 6 61.92 Quite High
Body Weight 8 53.00 Quite High
Primary Pulmonary Hypertension 96 50.00 Quite Low
Pneumonia 10 50.00 Quite Low
Injury 6 21.52 Low Low
Disease 95 5.00 Very Low Very Low Very Low
Parkinson's Disease 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B on downstream inflammatory mediators, we studied the abundance of the mRNA for intercellular adhesion molecule 1 (ICAM-1), which contains a consensus sequence for binding of NF-?
Positive_regulation (for) of Transcription (abundance) of intercellular adhesion molecule 1 associated with inflammatory mediators and adhesions
1) Confidence 0.24 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.25 Pain Relevance 0.15
In contrast, we observed no evidence for the activation of ICAM-1 transcription in the Fc?
Positive_regulation (activation) of Transcription (transcription) of ICAM-1
2) Confidence 0.24 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.16 Pain Relevance 0.07
B on downstream inflammatory mediators, we studied the abundance of the mRNA for intercellular adhesion molecule 1 (ICAM-1), which contains a consensus sequence for binding of NF-?
Positive_regulation (for) of Transcription (abundance) of ICAM-1 associated with inflammatory mediators and adhesions
3) Confidence 0.24 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.25 Pain Relevance 0.15
Lung mRNA levels of the inflammatory biomarkers VCAM-1, ICAM-1, and MCP-1, as well as of endothelin-1 (ET-1) were considerably higher after hypoxia than after normoxia, with no differences between IL-6-/- and wild-type mice (Figure 5).


Positive_regulation (higher) of Transcription (levels) of ICAM-1 in Lung associated with inflammation and hypoxia
4) Confidence 0.19 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.94 Pain Relevance 0.09
Lung mRNA levels of the inflammatory biomarkers VCAM-1, ICAM-1, and MCP-1, as well as of endothelin-1 (ET-1) were considerably higher after hypoxia than after normoxia, with no differences between IL-6-/- and wild-type mice (Figure 5).


Positive_regulation (after) of Transcription (levels) of ICAM-1 in Lung associated with inflammation and hypoxia
5) Confidence 0.19 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.94 Pain Relevance 0.09

General Comments

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