INT261599

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.55
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
Lung 1
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 159 100.00 Very High Very High Very High
Inflammatory mediators 6 99.66 Very High Very High Very High
ischemia 26 96.12 Very High Very High Very High
Inflammatory response 25 82.88 Quite High
Substantia nigra 111 82.00 Quite High
Inflammatory stimuli 1 77.92 Quite High
cytokine 68 77.80 Quite High
fibrosis 3 62.60 Quite High
chemokine 34 60.80 Quite High
dopaminergic neurodegeneration 15 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 174 100.00 Very High Very High Very High
Adhesions 66 100.00 Very High Very High Very High
Hypoxia 89 96.88 Very High Very High Very High
Cv Unclassified Under Development 26 96.12 Very High Very High Very High
Obesity 56 94.80 High High
Cirrhosis 15 94.44 High High
Injury 169 89.68 High High
Fibrosis 4 62.60 Quite High
Right Ventricular Hypertrophy 3 61.92 Quite High
Necrosis 8 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, mRNA levels of ICAM-1, TNF-?
Transcription (levels) of ICAM
1) Confidence 0.50 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.26 Pain Relevance 0.13
To index the inflammatory state, mRNA levels of ICAM-1 and MCP-1 were determined.
Transcription (levels) of ICAM associated with inflammation
2) Confidence 0.50 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 1.14 Pain Relevance 0.19
Pretreatment with topical polyethylene glycol hydrogel delivery of ICAM-1 antisense oligonucleotides demonstrated decreased ICAM-1 mRNA expression, reduced ICAM-1 protein staining, and decreased cellular damage in a murine partial nephrectomy/ischemia model [74].
Transcription (expression) of ICAM-1 associated with ischemia
3) Confidence 0.34 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.56 Pain Relevance 0.29
In contrast, we observed no evidence for the activation of ICAM-1 transcription in the Fc?
Transcription (transcription) of ICAM-1
4) Confidence 0.33 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.16 Pain Relevance 0.07
B on downstream inflammatory mediators, we studied the abundance of the mRNA for intercellular adhesion molecule 1 (ICAM-1), which contains a consensus sequence for binding of NF-?
Transcription (abundance) of ICAM-1 associated with inflammatory mediators and adhesions
5) Confidence 0.33 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.25 Pain Relevance 0.15
B on downstream inflammatory mediators, we studied the abundance of the mRNA for intercellular adhesion molecule 1 (ICAM-1), which contains a consensus sequence for binding of NF-?
Transcription (abundance) of intercellular adhesion molecule 1 associated with inflammatory mediators and adhesions
6) Confidence 0.33 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.25 Pain Relevance 0.15
Lung mRNA levels of the inflammatory biomarkers VCAM-1, ICAM-1, and MCP-1, as well as of endothelin-1 (ET-1) were considerably higher after hypoxia than after normoxia, with no differences between IL-6-/- and wild-type mice (Figure 5).


Transcription (levels) of ICAM-1 in Lung associated with inflammation and hypoxia
7) Confidence 0.22 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.93 Pain Relevance 0.09

General Comments

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