INT261600

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 6.22
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6ra) extracellular region (Il6ra) enzyme binding (Il6ra)
Anatomy Link Frequency
T cells 6
lung 4
joint 2
Stage 4 2
Il6ra (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 209 99.56 Very High Very High Very High
cytokine 97 91.36 High High
Central nervous system 66 89.88 High High
rheumatoid arthritis 2 75.00 Quite High
Inflammatory response 14 42.28 Quite Low
metalloproteinase 2 31.96 Quite Low
Arthritis 10 12.64 Low Low
chemokine 24 11.36 Low Low
Multiple sclerosis 36 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 122 100.00 Very High Very High Very High
Hypoxia 348 99.60 Very High Very High Very High
INFLAMMATION 211 99.56 Very High Very High Very High
Disease 58 98.72 Very High Very High Very High
Synovitis 4 94.88 High High
Hypercalcemia 12 94.08 High High
Multiple Sclerosis 150 90.16 High High
Central Nervous System Disease 63 89.88 High High
Arthritis 8 85.76 High High
Primary Pulmonary Hypertension 192 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Positive_regulation (increased) of Gene_expression (expression) of IL-6R in lung associated with hypoxia
1) Confidence 0.05 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.30 Pain Relevance 0.05
Combining IL-6 and sIL-6R further increased PA-SMC migration (Figure 6a).
Positive_regulation (increased) of Gene_expression (Combining) of sIL-6R
2) Confidence 0.05 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.89 Pain Relevance 0.03
Transwell migration assays showed that IL-6 (100 ng/ml) or sIL-6R (100 ng/ml) markedly stimulated human PA-SMC migration.
Positive_regulation (stimulated) of Gene_expression (migration) of sIL-6R
3) Confidence 0.05 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.93 Pain Relevance 0.04
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Positive_regulation (increased) of Gene_expression (levels) of IL-6R in lung associated with hypoxia
4) Confidence 0.05 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.30 Pain Relevance 0.05
In addition, we studied whether vitamin D3 negatively regulate the expression of IL-6R to inhibit TH17 differentiation but we did not see any significant differences in the IL-6R expression of CD4+ T cells after co-culture with IL-6, TGF-?
Positive_regulation (with) of Gene_expression (expression) of IL-6R in T cells
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.46 Pain Relevance 0.12
In addition, we studied whether vitamin D3 negatively regulate the expression of IL-6R to inhibit TH17 differentiation but we did not see any significant differences in the IL-6R expression of CD4+ T cells after co-culture with IL-6, TGF-?
Positive_regulation (culture) of Gene_expression (expression) of IL-6R in T cells
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.46 Pain Relevance 0.12
In addition, we studied whether vitamin D3 negatively regulate the expression of IL-6R to inhibit TH17 differentiation but we did not see any significant differences in the IL-6R expression of CD4+ T cells after co-culture with IL-6, TGF-?
Positive_regulation (with) of Gene_expression (expression) of IL-6R in T cells
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.53 Pain Relevance 0.13
Moreover, the sIL-6R:IL-6 ratio is significantly higher in patients with Stage 1 and 2 disease, according to Mallya and Mace [62, 63] assessment of disease activity, compared with patients with Stage 4 disease.
Positive_regulation (higher) of Gene_expression (ratio) of sIL-6R in Stage 4 associated with disease
8) Confidence 0.04 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 1.19 Pain Relevance 0.08
Elevated levels of IL-6 and sIL-6R in the SF of RA patients can increase the risk of joint destruction and, at the joint level, IL-6/sIL-6R can stimulate pannus development through increased VEGF expression and increase bone resorption as a result of osteoclastogenesis.
Positive_regulation (increase) of Gene_expression (levels) of sIL-6R in joint associated with rheumatoid arthritis and hypercalcemia
9) Confidence 0.04 Published 2010 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2789585 Disease Relevance 1.16 Pain Relevance 0.21

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