INT261617

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) mitochondrion (Comt) mRNA processing (SNRNP70)
RNA binding (SNRNP70) plasma membrane (Comt) nucleus (SNRNP70)
SNRNP70 (Homo sapiens)
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 46 100.00 Very High Very High Very High
Catecholamine 4 98.36 Very High Very High Very High
Pain 48 97.64 Very High Very High Very High
Analgesic 5 91.88 High High
noradrenaline 1 86.92 High High
Dopamine 1 86.32 High High
mu opioid receptor 3 70.48 Quite High
Morphine 84 61.68 Quite High
Cancer pain 9 60.24 Quite High
Opioid 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 50 97.64 Very High Very High Very High
Cancer Pain 9 60.24 Quite High
Cancer 16 50.00 Quite Low
Vomiting 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Fatigue 3 5.00 Very Low Very Low Very Low
Constipation 3 5.00 Very Low Very Low Very Low
Hantavirus Infection 3 5.00 Very Low Very Low Very Low
Dyspnea 3 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the influence on COMT activity by the Rs4680 (Val158Met) SNP and the well established involvement of catecholamines in pain perception [5-7], several studies have investigated if this SNP can explain interindividual variability in pain perception and efficacy of analgesics.
SNP Spec (investigated) Regulation (influence) of COMT associated with pain, catechol-o-methyltransferase, analgesic and catecholamine
1) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2644687 Disease Relevance 0.40 Pain Relevance 1.18

General Comments

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