INT261630

Context Info Confidence 0.02 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.69 Pain Relevance 0.15

nucleus (CPD, NHS) cell differentiation (NHS) peptidase activity (CPD)

CPD (Homo sapiens) NHS (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 14 76.48 Nicotine 17 76.04 alcohol 3 5.00 monoamine 3 5.00 withdrawal 1 5.00 Neurotransmitter 1 5.00 potassium channel 1 5.00 Dopamine 1 5.00 Opioid 1 5.00 Catecholamine 1 5.00

Disease Link Frequency Relevance Heat Nicotine Addiction 133 99.96 Lung Cancer 4 5.00 Cancer 4 5.00 Disease 2 5.00 Reprotox - General 1 1 5.00 Parkinson's Disease 1 5.00 Syndrome 1 5.00 Breast Cancer 1 5.00 Alcohol Addiction 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Figure 3 and Table S3 summarize the associations between genotyped and imputed SNPs and CPD in PLCO and NHS smokers for the chr15q25.1 region spanning CHRNA3 and CHRNA5.

CPD Binding (associations) of NHS associated with nicotine addiction

1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644817 Disease Relevance 0.69 Pain Relevance 0.15

General Comments

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