INT261650

Context Info Confidence 0.04 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.71 Pain Relevance 0.24

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1) DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)

LGR6 (Homo sapiens) MAPK1 (Homo sapiens)

Pain Link Frequency Relevance Heat bradykinin 75 99.92 Inflammation 20 5.00 Eae 3 5.00 imagery 3 5.00 cerebral cortex 1 5.00 b2 receptor 1 5.00 Pain 1 5.00 Neuropeptide 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Disease 193 91.28 Stress 102 71.68 Apoptosis 24 5.00 INFLAMMATION 20 5.00 Down Syndrome 16 5.00 Alzheimer's Dementia 3 5.00 Injury 3 5.00 Neurodegenerative Disease 2 5.00 Head Trauma 2 5.00 Photophobia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ERK, traditionally viewed as responsive to activation of growth factor receptors, was here activated by the GPCR BKB2 receptor.

GPCR BKB2 receptor Positive_regulation (activated) of ERK

1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.71 Pain Relevance 0.24

General Comments

This test has worked.