INT26167

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Context Info
Confidence 0.23
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 8.67
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Hrasls) cytoplasm (Hrasls)
Anatomy Link Frequency
nociceptor 2
plasma 1
SH2 1
internal 1
Hrasls (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 18 99.74 Very High Very High Very High
Inflammation 169 99.64 Very High Very High Very High
substance P 12 99.26 Very High Very High Very High
Nicotine 1 99.22 Very High Very High Very High
depression 40 98.98 Very High Very High Very High
Endocannabinoid 11 98.88 Very High Very High Very High
antagonist 52 97.96 Very High Very High Very High
Kinase C 17 97.32 Very High Very High Very High
Inflammatory mediators 1 96.24 Very High Very High Very High
cytokine 149 94.72 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 10 100.00 Very High Very High Very High
Nicotine Addiction 12 99.98 Very High Very High Very High
Disease 304 99.84 Very High Very High Very High
INFLAMMATION 182 99.64 Very High Very High Very High
Nociception 62 99.52 Very High Very High Very High
Infection 12 99.44 Very High Very High Very High
Depression 40 98.98 Very High Very High Very High
Stress 10 98.84 Very High Very High Very High
Age-related Macular Degeneration 246 96.84 Very High Very High Very High
Targeted Disruption 48 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like N/OFQ, nocistatin-induced nociception was abolished by i.pl. injection of pertussis toxin, phospholipase C inhibitor, or CP-99994, a neurokinin 1 receptor antagonist, indicating that nocistatin may elicit nociception through a substance P release from nociceptor endings via activation of Gi/o and phospholipase C.
Positive_regulation (activation) of phospholipase in nociceptor associated with nociception, bordatella infection, nociceptor, antagonist and substance p
1) Confidence 0.23 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12665541 Disease Relevance 0.82 Pain Relevance 0.86
The data are consistent with a model in which all these factors impinge on the Na+/Ca2+ exchanger regulating internal Ca2+ that, in turn, activates phospholipase C.
Positive_regulation (activates) of phospholipase in internal
2) Confidence 0.17 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2550841 Disease Relevance 0 Pain Relevance 0.35
Like N/OFQ, nocistatin-induced nociception was abolished by i.pl. injection of pertussis toxin, phospholipase C inhibitor, or CP-99994, a neurokinin 1 receptor antagonist, indicating that nocistatin may elicit nociception through a substance P release from nociceptor endings via activation of Gi/o and phospholipase C.
Positive_regulation (injection) of phospholipase in nociceptor associated with nociception, bordatella infection, nociceptor, antagonist and substance p
3) Confidence 0.17 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12665541 Disease Relevance 0.73 Pain Relevance 0.79
All these findings strongly suggest that herbicide atrazine exerts inflammatory activity through activation of putative G(q/11)-coupled neurosteroid receptor and phospholipase C.
Positive_regulation (activation) of phospholipase associated with inflammation
4) Confidence 0.16 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16381660 Disease Relevance 0.26 Pain Relevance 0.14
These analyses revealed that the degranulation is mediated by putative metabotropic neurosteroid receptor, G(q/11), phospholipase C and Ca(2+) mobilization from intracellular stores.
Positive_regulation (metabotropic) of phospholipase
5) Confidence 0.12 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16381660 Disease Relevance 0.17 Pain Relevance 0.15
Second, nicotine and cotinine in the plasma of smokers activates retinal phospholipase A2, causing the formation of arachidonic acid (Sastry & Hemontolor 1998), a precursor to the inflammatory mediators prostaglandins and leukotrienes, which may contribute to macular degeneration (Sastry & Hemontolor 1998).
Positive_regulation (activates) of phospholipase in plasma associated with inflammatory mediators, nicotine addiction, nicotine and age-related macular degeneration
6) Confidence 0.05 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.77 Pain Relevance 0.16
The endocannabinoid -LTD was presynaptically expressed and depended on the activation of postsynaptic mGluR5, phospholipase C and a rise in postsynaptic Ca2+ as predicted from the localization of the different components of the endocannabinoid system.
Positive_regulation (activation) of phospholipase associated with endocannabinoid and depression
7) Confidence 0.05 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1933592 Disease Relevance 0.72 Pain Relevance 0.73
This group of receptors signals through Src family kinase-dependent phosphorylation of the conserved tyrosines in the ITAM leading to recruitment of a Syk family kinase via its tandem SH2 domains, and stimulation of a downstream signaling cascade, which results in activation of phospholipase C (PLC) ?.
Positive_regulation (activation) of phospholipase in SH2
8) Confidence 0.04 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
2 to the membrane, with SLP-76 being essential for tyrosine phosphorylation and activation of the phospholipase.
Positive_regulation (activation) of phospholipase
9) Confidence 0.03 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.14 Pain Relevance 0
A recent lipidomic study showed that cytosolic phospholipase A2 (cPLA2; GIVA PLA2), a phospholipase that releases AA from phospholipids, is activated in AD and AD model mice, resulting in elevations of all of AA's different COX and lipoxygenase (LOX) metabolites.
Positive_regulation (is activa) of phospholipase associated with disease
10) Confidence 0.03 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 1.02 Pain Relevance 0.34
Aminoglycosides that resist to degradation can induce an alteration of the lysosomal phospholipase, a modified permeability of lysosomal membranes and a reduction in catabolism of renal proteins inducing phospholipidosis.
Positive_regulation (induce) of phospholipase
11) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.77 Pain Relevance 0
A recent lipidomic study showed that cytosolic phospholipase A2 (cPLA2; GIVA PLA2), a phospholipase that releases AA from phospholipids, is activated in AD and AD model mice, resulting in elevations of all of AA's different COX and lipoxygenase (LOX) metabolites.
Positive_regulation (activated) of phospholipase associated with disease
12) Confidence 0.03 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 1.01 Pain Relevance 0.33
1d-AR can result in the activation of phospholipase A2 in COS-1 cells (20); the ?
Positive_regulation (activation) of phospholipase
13) Confidence 0.02 Published 2010 Journal Journal of Receptor and Signal Transduction Research Section Body Doc Link PMC3018134 Disease Relevance 0 Pain Relevance 0
P2X7 receptor operation also is associated with activation of various transcription factors [119, 120], enhanced production of reactive oxygen species [121], mitochondrial membrane depolarization [122], and activation of phospholipase D [123].
Positive_regulation (activation) of phospholipase
14) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
The P2Y6 receptor is a Gq-coupled receptor [13, 46, 47] and thus is expected to promote activation of phospholipase C leading to the generation of inositol-1,4,5-triphosphate and elevation of intracellular Ca2+ levels.
Positive_regulation (activation) of phospholipase
15) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.08 Pain Relevance 0.33
Activation of the RhoA GTPase and phospholipase d-dependent acidification of phagolysosomes can have profound effects on viral and bacterial entry into cells and also on the intracellular killing of bacteria.
Positive_regulation (Activation) of phospholipase
16) Confidence 0.02 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.82 Pain Relevance 0.21
Activation of phospholipase D produces anandamide, which can subsequently be converted to AA by fatty acid amide hydrolase [1].
Positive_regulation (Activation) of phospholipase
17) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.17 Pain Relevance 0.26
Activation of phospholipase C (PLC) hydrolyzes phosphatidyl inositol 4, 5 bisphosphate (PIP2) to inositol 1, 4, 5 trisphosphate (IP3) and diacyl glycerol (DAG).
Positive_regulation (Activation) of phospholipase
18) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.19 Pain Relevance 0.21

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