INT261676

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.59
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PSEN1) Golgi apparatus (PSEN1) endoplasmic reticulum (PSEN1)
embryo development (PSEN1) peptidase activity (PSEN1) cell death (PSEN1)
PSEN1 (Homo sapiens)
PSEN1 - M146L (1)
Pain Link Frequency Relevance Heat
bradykinin 75 100.00 Very High Very High Very High
Inflammation 20 99.64 Very High Very High Very High
Eae 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
b2 receptor 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 102 99.78 Very High Very High Very High
INFLAMMATION 20 99.64 Very High Very High Very High
Apoptosis 24 94.00 High High
Disease 193 89.84 High High
Down Syndrome 16 72.84 Quite High
Alzheimer's Dementia 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Head Trauma 2 5.00 Very Low Very Low Very Low
Photophobia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since inflammatory stress yielded a diminished BK-induced activation of all three MAPK modules in PS-1 M146L, we initially assumed that oxidative stress would likely have a similar effect.
Negative_regulation (diminished) of Positive_regulation (activation) of PS-1 (M146L) associated with stress, inflammation and bradykinin
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.59 Pain Relevance 0.25

General Comments

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