INT261685

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 150 97.24 Very High Very High Very High
Inflammation 96 89.56 High High
imagery 6 81.56 Quite High
cytokine 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 204 97.52 Very High Very High Very High
INFLAMMATION 108 89.56 High High
Disease 402 84.16 Quite High
Apoptosis 52 82.60 Quite High
Down Syndrome 32 34.68 Quite Low
Periodontitis 34 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Periodontal Disease 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total cellular levels of ERK, JNK, and p38 proteins did not change significantly over the time courses of up to 1 hour incubation with BK or H2O2.


Neg (not) Regulation (change) of Gene_expression (levels) of JNK associated with bradykinin
1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0 Pain Relevance 0.09
Cell lysates collected in 1% SDS were immunoblotted for expression and activation of ERK, JNK and p38 and normalized to the loading control protein tubulin.
Regulation (immunoblotted) of Gene_expression (expression) of JNK
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.36 Pain Relevance 0.25
For the three cell lines used, differential expression of the genes included in the GO categories "positive regulation of JNK cascade" and "positive regulation of I-kappaB kinase/NF-kappaB cascade" in the 1 h to 3 h comparison is also displayed in a heat map in Figure 5.
Regulation (regulation) of Gene_expression (cascade) of JNK
3) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
Interestingly, positive regulation of two distinct signaling pathways, "positive regulation of I-kappaB kinase/NF-kappaB cascade" and "positive regulation of JNK cascade", was identified by the enrichment analysis in the comparison of 1 h and 3 h of TNF?
Regulation (regulation) of Gene_expression (cascade) of JNK
4) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.08 Pain Relevance 0

General Comments

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