INT261712

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.03
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GABRB3) transport (GABRB3) plasma membrane (GABRB3)
transmembrane transport (GABRB3)
Anatomy Link Frequency
DRG 1
GABRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 117 99.94 Very High Very High Very High
nMDA receptor 1 99.80 Very High Very High Very High
pregabalin 63 99.72 Very High Very High Very High
dorsal root ganglion 13 99.28 Very High Very High Very High
5HT 4 98.80 Very High Very High Very High
cannabis 52 98.76 Very High Very High Very High
anticonvulsant 6 98.68 Very High Very High Very High
unmyelinated 38 97.76 Very High Very High Very High
Antinociceptive 1 97.28 Very High Very High Very High
tetrodotoxin 1 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 13 99.28 Very High Very High Very High
Schizophrenia 106 97.16 Very High Very High Very High
Anxiety Disorder 16 96.54 Very High Very High Very High
Epilepsy 2 95.60 Very High Very High Very High
Drug Dependence 43 94.88 High High
Cannabis Dependence 24 93.24 High High
Disease 40 88.24 High High
Syndrome 3 87.60 High High
Lifespan 27 86.40 High High
Fibromyalgia 147 81.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional GABAA receptor mediated responses in the somata of DRG neurones is also evident in their unmyelinated axons (rat: [11]) where application of GABA results in depolarization (for review see [12], [13]).
Regulation (responses) of GABAA receptor in DRG associated with dorsal root ganglion, gaba and unmyelinated
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.44 Pain Relevance 0.53
GABA-A receptor beta-2 subunit is a target for clomethiazole (sedative and anticonvulsant), Na (V) I alpha is a target for drugs such as levetiracetam (epilepsy), tetrodotoxin (anesthetics), toprimate (anticonsulvant) and SCN10A is target for bupivacaine racemic (anesthetics) and lidocaine (anesthetics).
Regulation (target) of receptor beta-2 subunit associated with epilepsy, tetrodotoxin, gaba, anticonvulsant and lidocaine
2) Confidence 0.06 Published 2008 Journal BMC Biol Section Body Doc Link PMC2645369 Disease Relevance 0.25 Pain Relevance 0.33
The expression patterns for individual proteins can be characterized as either no change (GAD67, GABAA?
Regulation (change) of GABAA
3) Confidence 0.05 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.09 Pain Relevance 0.36
This finding suggests an increased alteration of GABAA and NMDA receptor activity in cannabis-abusing first-episode patients as compared to schizophrenia patients with no history of substance abuse.
Regulation (alteration) of GABAA associated with cannabis, drug abuse, nmda receptor and schizophrenia
4) Confidence 0.03 Published 2009 Journal Psychopharmacology (Berl) Section Abstract Doc Link PMC2806533 Disease Relevance 1.57 Pain Relevance 0.45
Figure 1 illustrates the promiscuous modulation of four LGICs (GABAA, acetylcholine, glycine, and 5HT-3 receptors) by 170 compounds identified in a systematic manual search of the PubMed database between 1970 and 2008, as demonstrated by in vitro electrophysiology studies.
Regulation (modulation) of GABAA associated with 5ht
5) Confidence 0.01 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2838756 Disease Relevance 0 Pain Relevance 0.12
Pregabalin has exhibited anxiolytic, anticonvulsant, and antinociceptive properties in human and animal studies.24 Despite its structural similarity to GABA (gamma-aminobutyric acid), pregabalin is devoid of effects on GABAA, GABAB, and benzodiazepine receptors.
Regulation (effects) of GABAA associated with pregabalin, gaba, anxiety disorder, anticonvulsant and antinociceptive
6) Confidence 0.01 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 0.69 Pain Relevance 1.35

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