INT26173

Context Info Confidence 0.52 First Reported 1989 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 3.40 Pain Relevance 0.32

endoplasmic reticulum (SELS) plasma membrane (SELS) enzyme binding (SELS) cytoplasm (SELS)

Anatomy Link Frequency adipose tissue 1 brachial plexus 1 SELS (Homo sapiens)

Pain Link Frequency Relevance Heat carpal tunnel syndrome 1 97.66 cytokine 8 80.96 Inflammation 12 77.28 Peripheral nervous system 1 75.00 rheumatoid arthritis 2 74.56 Inflammatory marker 6 69.72 Pain 1 10.00 Angina 8 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 42 99.84 Disease 2 99.12 Injury 3 98.28 Obesity 142 97.92 Carpal Tunnel Syndrome 1 97.66 Nerve Root Compression 2 96.92 Neuropathy 2 96.52 Peripheral Neuropathy 1 96.10 Disorder Of Lipid Metabolism 24 96.04 Metabolic Syndrome 2 79.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SIGNIFICANCE: Response inhibition significantly modulates both LEPs and SEPs.

Regulation (modulates) of SEPs

1) Confidence 0.52 Published 2007 Journal Clin Neurophysiol Section Body Doc Link 17475550 Disease Relevance 0.05 Pain Relevance 0

Previous studies have suggested that the SELS gene is dysregulated in diabetes, and the data presented here indicate that the C3705T and/or the A5227G polymorphisms may play a role in this context.

Regulation (dysregulated) of SELS associated with diabetes mellitus

2) Confidence 0.27 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.01 Pain Relevance 0.19

Previous studies suggest a difference in SELS gene regulation depending on type 2 diabetes mellitus status in both subcutaneous [5] and omental adipose tissue [7].

Regulation (regulation) of SELS in adipose tissue associated with diabetes mellitus and obesity

3) Confidence 0.27 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.39 Pain Relevance 0

A study of 100 patients with peripheral nerve diseases: 30 polyneuropathies, 50 radiculopathies, 9 cases with carpal tunnel syndrome, 5 with brachial plexus injury, 6 with compressive or traumatic diseases of the peripheral nerves, demonstrates the value of the SEPs in the assessment of the nervous lesion site (central or peripheral).

Regulation (value) of SEPs in brachial plexus associated with nerve root compression, neuropathy, injury, carpal tunnel syndrome, peripheral neuropathy and disease

4) Confidence 0.02 Published 1989 Journal Neurol Psychiatr (Bucur) Section Abstract Doc Link 2551030 Disease Relevance 0.95 Pain Relevance 0.14

General Comments

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