INT261753

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.49
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat6) nucleus (Stat6) DNA binding (Stat6)
cytoplasm (Stat6) signal transducer activity (Stat6)
Anatomy Link Frequency
lung 2
Stat6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 56 69.16 Quite High
Inflammatory mediators 2 52.48 Quite High
cytokine 56 52.44 Quite High
Arthritis 4 44.16 Quite Low
chemokine 16 35.12 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 6 100.00 Very High Very High Very High
Candida Infection 274 99.90 Very High Very High Very High
Eosinophilia 2 78.04 Quite High
Hypersensitivity 59 76.20 Quite High
INFLAMMATION 50 69.16 Quite High
Fungal Infection 2 66.72 Quite High
Necrosis 2 54.16 Quite High
Cancer 2 53.80 Quite High
Arthritis 4 44.16 Quite Low
Peritonitis 2 43.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to increase our ability to detect phosphorylation of STAT-6, nuclear protein extracts from lung tissue were used.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of STAT-6 in lung
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0.03
Moreover, we have previously found that a single intratracheal administration of CSBG can induce mucus hyperplasia, one of the consequences of the Th2 (IL-13)-dominant response and the enhanced phosphorylation of STAT6, one of the pivotal transcriptional factors in the Th2 milieu [42].
Positive_regulation (induce) of Phosphorylation (phosphorylation) of STAT6 associated with hyperplasia and candida infection
2) Confidence 0.26 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.32 Pain Relevance 0.06
Moreover, we have previously found that a single intratracheal administration of CSBG can induce mucus hyperplasia, one of the consequences of the Th2 (IL-13)-dominant response and the enhanced phosphorylation of STAT6, one of the pivotal transcriptional factors in the Th2 milieu [42].
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of STAT6 associated with hyperplasia and candida infection
3) Confidence 0.26 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.17 Pain Relevance 0.03

General Comments

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