INT26177

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 11.32
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
skeletal muscles 4
body 4
adipocytes 3
liver 1
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 9 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
addiction 3 100.00 Very High Very High Very High
isoflurane 1 100.00 Very High Very High Very High
narcan 7 99.98 Very High Very High Very High
antagonist 2 99.32 Very High Very High Very High
opiate 3 99.10 Very High Very High Very High
Somatostatin 5 98.96 Very High Very High Very High
opioid receptor 1 96.44 Very High Very High Very High
Dismenorea 2 93.60 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 438 100.00 Very High Very High Very High
Obesity 303 99.70 Very High Very High Very High
Anxiety Disorder 1 99.40 Very High Very High Very High
Breast Cancer 7 98.16 Very High Very High Very High
Body Weight 27 97.48 Very High Very High Very High
Diabetes Mellitus 189 97.24 Very High Very High Very High
Cancer 77 96.64 Very High Very High Very High
Weight Loss 20 93.76 High High
Reprotox - General 1 2 93.60 High High
Impaired Glucose Tolerance 45 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different tissues differ in their dependence on insulin for glucose uptake, skeletal muscles, liver, fat cells and abdominal viscera being among the most insulin dependent and brain, red blood cells and placenta being among the most insulin independent ones.
Regulation (differ) of Regulation (dependence) of insulin in skeletal muscles associated with addiction and obesity
1) Confidence 0.44 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 0.70 Pain Relevance 0.05
Naloxone (5 mg), an opiate antagonist, did not produce any significant change in the insulin and glucagon responses to beta-endorphin, while somatostatin (0.25 mg/h) completely abolished the hormonal responses to the opioid.
Regulation (change) of Regulation (responses) of insulin associated with antagonist, somatostatin, narcan, opiate and opioid
2) Confidence 0.41 Published 1987 Journal Diabete Metab Section Abstract Doc Link 2896134 Disease Relevance 0.38 Pain Relevance 0.58
The present studies were undertaken to characterize further the influence of synthetic human beta-endorphin (0.5 mg/h) on insulin and glucagon responses to intravenous glucose in humans.
Regulation (influence) of Regulation (responses) of insulin
3) Confidence 0.35 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2551176 Disease Relevance 0.08 Pain Relevance 0
Moreover, these results suggest that changes in serum leptin and insulin concentrations are independent on the etiology of chronic pancreatitis.


Neg (independent) Regulation (independent) of Regulation (changes) of insulin
4) Confidence 0.34 Published 2008 Journal Pancreas Section Body Doc Link 18376301 Disease Relevance 0 Pain Relevance 0
Moreover in obese patients we evaluated the effect of this anti-opioid drug on insulin secretion and insulin sensitivity during an IVGTT using the minimal model approach.
Regulation (effect) of Regulation (sensitivity) of insulin associated with obesity and opioid
5) Confidence 0.27 Published 1994 Journal Horm. Metab. Res. Section Abstract Doc Link 8082873 Disease Relevance 0.41 Pain Relevance 0.37
Insulin sensitivity was greatly impaired by anesthesia with isoflurane, but was not affected by use of the anxiolytic agent diazepam.
Neg (not) Regulation (affected) of Regulation (sensitivity) of Insulin associated with anesthesia, anxiety disorder and isoflurane
6) Confidence 0.27 Published 2003 Journal Comp. Med. Section Abstract Doc Link 12625507 Disease Relevance 1.29 Pain Relevance 0.24
Evaluation of multivariate correlation showed that the beneficial effect of Paleolithic diet on insulin sensitivity and insulin response was independent of all other relevant study variables such as body weight, subcutaneous fat thickness and body temperature.
Regulation (effect) of Regulation (sensitivity) of insulin in body associated with body weight
7) Confidence 0.23 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1635051 Disease Relevance 0.24 Pain Relevance 0.08
Evaluation of multivariate correlation showed that the beneficial effect of Paleolithic diet on insulin sensitivity and insulin response was independent of all other relevant study variables such as body weight, subcutaneous fat thickness and body temperature.
Regulation (effect) of Regulation (response) of insulin in body associated with body weight
8) Confidence 0.23 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1635051 Disease Relevance 0.24 Pain Relevance 0.08
Insulin resistance/sensitivity and free IGF-1 levels shall be determined in all subjects.
Regulation (resistance) of Regulation (sensitivity) of Insulin associated with insulin resistance
9) Confidence 0.19 Published 2007 Journal BMC Endocr Disord Section Abstract Doc Link PMC2151943 Disease Relevance 1.37 Pain Relevance 0
Insulin resistance/sensitivity and free IGF-1 levels shall be determined in all subjects.
Regulation (sensitivity) of Regulation (resistance) of Insulin associated with insulin resistance
10) Confidence 0.19 Published 2007 Journal BMC Endocr Disord Section Abstract Doc Link PMC2151943 Disease Relevance 1.37 Pain Relevance 0
The adipose tissue and the adipocytes are important targets for insulin control of energy metabolism.
Regulation (targets) of Regulation (control) of insulin in adipocytes associated with obesity
11) Confidence 0.18 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.46 Pain Relevance 0
The unchanged BMI of subjects treated with rosiglitazone and the relationship between the change in insulin sensitivity and circulating fH levels suggest that insulin resistance is a driving force in the induction of increased fH levels.
Regulation (change) of Regulation (sensitivity) of insulin associated with insulin resistance
12) Confidence 0.17 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.61 Pain Relevance 0.04
Different tissues differ in their dependence on insulin for glucose uptake, skeletal muscles, liver, fat cells and abdominal viscera being among the most insulin dependent and brain, red blood cells and placenta being among the most insulin independent ones.
Regulation (differ) of in liver Regulation (dependence) of insulin in skeletal muscles associated with addiction and obesity
13) Confidence 0.15 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 0.70 Pain Relevance 0.05
Different tissues differ in their dependence on insulin for glucose uptake, skeletal muscles, liver, fat cells and abdominal viscera being among the most insulin dependent and brain, red blood cells and placenta being among the most insulin independent ones.
Regulation (differ) of in fat cells Regulation (dependence) of insulin in skeletal muscles associated with addiction and obesity
14) Confidence 0.15 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 0.70 Pain Relevance 0.05
Concomitant infusion of naloxone altered neither the basal concentrations of glucose, insulin, and glucagon nor the responses of these measures to the glucose challenge.
Neg (neither) Regulation (altered) of Neg (nor) Regulation (responses) of insulin associated with narcan
15) Confidence 0.13 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3517030 Disease Relevance 0.48 Pain Relevance 0.53
Interestingly, the lower the RBP4 concentration, the higher the change in insulin sensitivity after iron depletion.
Regulation (change) of Regulation (sensitivity) of insulin
16) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.15 Pain Relevance 0
Our findings imply that iron stores could independently affect RBP4 levels and insulin sensitivity.
Regulation (affect) of Regulation (sensitivity) of insulin
17) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.23 Pain Relevance 0
Importantly, insulin effects on ERK1/2 (Fig. 3A and B) and on protein kinase B (PKB) phosphorylation were not modified (supplementary Fig.
Neg (not) Regulation (modified) of Regulation (effects) of insulin
18) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.38 Pain Relevance 0.10
A sample of healthy controls participating in the SHINE (Southwest Hormone, Insulin, Nutrition, and Exercise Study) case-control breast cancer in Arizona, Colorado, New Mexico, and Utah were included in these analyses.
Regulation (controls) of Regulation (participating) of Insulin associated with breast cancer
19) Confidence 0.01 Published 2005 Journal Cancer Causes Control Section Abstract Doc Link 16215864 Disease Relevance 0.34 Pain Relevance 0

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