INT261776

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 2
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 11 99.80 Very High Very High Very High
Glutamate receptor 2 99.16 Very High Very High Very High
tetrodotoxin 3 98.68 Very High Very High Very High
sodium channel 1 97.64 Very High Very High Very High
gABA 36 86.16 High High
Calcium channel 4 73.00 Quite High
agonist 6 69.04 Quite High
antagonist 4 54.52 Quite High
midbrain 1 49.28 Quite Low
bDMF 10 24.24 Low Low
Disease Link Frequency Relevance Heat
Convulsion 30 50.00 Quite Low
Epilepsy 22 5.00 Very Low Very Low Very Low
Status Epilepticus 3 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low
Hepatic Encephalopathy 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On a separate note, Ludwig et al. did not observe any changes in KCC2 immunoreactivity in cultured PN0-1 hippocampal mouse neurons chronically treated with either picrotoxin and the sodium channel inhibitor tetrodotoxin (TTX) or combinations of TTX with glutamate receptor inhibitors, proposing that these are not necessary for the developmental increase in KCC2, in hippocampus [180].
Neg (not) Positive_regulation (necessary) of Positive_regulation (increase) of KCC2 in neurons associated with tetrodotoxin, glutamate receptor, sodium channel and hippocampus
1) Confidence 0.37 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox