INT261782

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) plasma membrane (Slc12a5) intracellular (Slc12a5)
cytoplasmic membrane-bounded vesicle (Bdnf) transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 2
Bdnf (Rattus norvegicus)
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 10 100.00 Very High Very High Very High
Limbic system 1 92.76 High High
Neuronal excitability 1 88.00 High High
Hippocampus 11 40.92 Quite Low
Glutamate receptor 2 36.68 Quite Low
tetrodotoxin 3 35.72 Quite Low
sodium channel 1 33.64 Quite Low
gABA 36 24.52 Low Low
Calcium channel 4 11.36 Low Low
agonist 6 7.40 Low Low
Disease Link Frequency Relevance Heat
Convulsion 30 50.00 Quite Low
Stress 2 35.68 Quite Low
Epilepsy 22 5.00 Very Low Very Low Very Low
Status Epilepticus 3 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low
Hepatic Encephalopathy 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In developing neurons, BDNF increases KCC2 expression [3, 35], whereas in mature neurons BDNF decreases KCC2 and causes a positive shift of EGABA [262, 263, 317].
BDNF Positive_regulation (increases) of Gene_expression (expression) of KCC2 in neurons associated with bdmf
1) Confidence 0.18 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0 Pain Relevance 0.44

General Comments

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