INT261786

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.05
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) plasma membrane (Slc12a5) intracellular (Slc12a5)
cytoplasmic membrane-bounded vesicle (Bdnf) transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 1
Bdnf (Rattus norvegicus)
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 20 100.00 Very High Very High Very High
Limbic system 2 90.12 High High
Neuronal excitability 2 85.36 High High
Hippocampus 22 38.28 Quite Low
Glutamate receptor 4 34.04 Quite Low
tetrodotoxin 6 33.08 Quite Low
sodium channel 2 31.00 Quite Low
gABA 72 21.88 Low Low
Calcium channel 8 8.72 Low Low
agonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 52.00 Quite High
Convulsion 60 50.00 Quite Low
Epilepsy 44 5.00 Very Low Very Low Very Low
Status Epilepticus 6 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Hepatic Encephalopathy 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rivera et al. identified trkB as the receptor involved in BDNF-mediated downregulation of KCC2 [263].
BDNF Negative_regulation (downregulation) of KCC2 associated with bdmf
1) Confidence 0.14 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.05 Pain Relevance 0.42
In developing neurons, BDNF increases KCC2 expression [3, 35], whereas in mature neurons BDNF decreases KCC2 and causes a positive shift of EGABA [262, 263, 317].
BDNF Negative_regulation (decreases) of KCC2 in neurons associated with bdmf
2) Confidence 0.14 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0 Pain Relevance 0.43

General Comments

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