INT26181

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 1.03
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
pituitary 4
medulla 2
lacrimal 2
anterior pituitary 2
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 56 100.00 Very High Very High Very High
opioid receptor 10 99.82 Very High Very High Very High
alcohol 8 99.74 Very High Very High Very High
qutenza 4 99.48 Very High Very High Very High
antagonist 22 99.36 Very High Very High Very High
Analgesic 12 98.96 Very High Very High Very High
agonist 17 98.58 Very High Very High Very High
Dopamine 1 98.40 Very High Very High Very High
opiate 5 98.06 Very High Very High Very High
narcan 12 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2 96.76 Very High Very High Very High
Pain 34 92.68 High High
Alcohol Addiction 4 89.60 High High
Cushing's Syndrome /

Hypercortisolism

1 83.12 Quite High
Decapitation 1 78.28 Quite High
Weight Gain 1 76.96 Quite High
Gastric Fistula 1 69.44 Quite High
Adrenal Insufficiency 6 50.08 Quite High
Nociception 24 50.00 Quite Low
Disorders Of The Lacrimal System 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it has also been observed that habitual alcohol consumption leads to a beta-endorphin deficiency.
Positive_regulation (leads) of Negative_regulation (deficiency) of beta-endorphin associated with alcohol
1) Confidence 0.70 Published 2005 Journal Peptides Section Abstract Doc Link 15752586 Disease Relevance 0.25 Pain Relevance 0.51
To simplify dosing and to increase suppression of ACTH, synthetic glucocorticoids such as prednisone, prednisolone, methylprednisolone, and dexamethasone may be employed.
Positive_regulation (increase) of Negative_regulation (suppression) of ACTH associated with dexamethasone
2) Confidence 0.54 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.13 Pain Relevance 0.20
Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic beta-endorphin, a specific antiserum and human beta-endorphin fragment 6 31, a peptidergic beta-endorphin antagonist have been used in the attempt of selectively affecting the function of beta-endorphinergic system and of evaluating the possible role of this peptide in the analgesic effect of morphine.
Positive_regulation (induces) of Negative_regulation (decrease) of beta-endorphin associated with qutenza, analgesic, antagonist and morphine
3) Confidence 0.50 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 2951622 Disease Relevance 0 Pain Relevance 0.70
Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic beta-endorphin, a specific antiserum and human beta-endorphin fragment 6 31, a peptidergic beta-endorphin antagonist have been used in the attempt of selectively affecting the function of beta-endorphinergic system and of evaluating the possible role of this peptide in the analgesic effect of morphine.
Positive_regulation (induces) of Negative_regulation (decrease) of beta-endorphin associated with qutenza, analgesic, antagonist and morphine
4) Confidence 0.50 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 2951622 Disease Relevance 0 Pain Relevance 0.68
We provide evidence that both Diclofenac and Pirprofen, two cyclooxygenase inhibitors with a potent analgesic effect both in the experimental animal and in man, induce a significant and long lasting decrease in pituitary beta-endorphin concentrations, together with an increase of the hypothalamic concentrations of the peptide.
Positive_regulation (induce) of Negative_regulation (decrease) of beta-endorphin in pituitary associated with analgesic and diclofenac
5) Confidence 0.49 Published 1985 Journal Pharmacol Res Commun Section Abstract Doc Link 2931730 Disease Relevance 0 Pain Relevance 0.27
These results indicate that D can induce a significant decline in plasma levels of ACTH, beta-lipotropin, and beta-endorphin, the major circulating peptides from the C-terminal part of proopiocortin, and suggest that opioid peptides may be involved in the control of the functional activity of pituitary-adrenocortical activity in man.
Positive_regulation (induce) of Negative_regulation (decline) of beta-endorphin in pituitary associated with opioid
6) Confidence 0.47 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.18
Glucose-induced glucagon suppression was significantly lower during beta-endorphin, a fact that could have contributed to the reduced glucose utilization rates.
Positive_regulation (induced) of Negative_regulation (suppression) of beta-endorphin
7) Confidence 0.44 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2551176 Disease Relevance 0.10 Pain Relevance 0
An in vitro approach was used to determine the opioid receptor subtype mediating beta-endorphin inhibition of endogenous norepinephrine release from the A2 nucleus in the caudal dorsomedial medulla of rats.
Spec (determine) Positive_regulation (mediating) of Spec (determine) Negative_regulation (inhibition) of beta-endorphin in medulla associated with medulla and opioid receptor
8) Confidence 0.43 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9288827 Disease Relevance 0 Pain Relevance 0.39
Treatment with the dopamine agonists bromocriptine or apomorphine had no effect, but haloperidol treatment increased anterior pituitary Met-enkephalin which was reversed by concomitant bromocriptine administration.
Positive_regulation (increased) of Negative_regulation (reversed) of Met-enkephalin in anterior pituitary associated with dopamine, agonist and enkephalin
9) Confidence 0.41 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 2830550 Disease Relevance 0 Pain Relevance 0.88
In contrast, the lower formalin concentration induced a marked increase in locomotion and rearing and a decrease in ACTH levels.
Positive_regulation (induced) of Negative_regulation (decrease) of ACTH
10) Confidence 0.28 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7566433 Disease Relevance 0.40 Pain Relevance 0.32
No change in Mycobacterium butyricum-triggered opioid peptide release was seen after blockade with single or combined anti-TLR-2 and anti-TLR-4 (Fig. 6A) while the addition of two FPR antagonists, Boc-FLFLF and cyclosporine H, resulted in an 80% and 74% reduction of Met-enkephalin release, respectively (Fig. 6B and Table 2).
Positive_regulation (resulted) of Negative_regulation (reduction) of Met-enkephalin release associated with antagonist, enkephalin and opioid
11) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0 Pain Relevance 0.79
Naloxone, a mu opiate antagonist (mu/delta, 27:1), also inhibited the 2DG gastric secretory response by about 50% and augmented the Met-enkephalin inhibition of secretion without blocking either the secretory rebound or the effect on gastrin release.
Positive_regulation (augmented) of Negative_regulation (inhibition) of Met-enkephalin associated with antagonist, narcan, enkephalin and opiate
12) Confidence 0.16 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6809930 Disease Relevance 0.07 Pain Relevance 1.23
CONCLUSIONS: These results demonstrate that met-enkephalin inhibition of cholinergic secretion is mediated by way of the pertussis toxin-sensitive G proteins Gi2 and Gi3 in cultured rabbit lacrimal acini.
Positive_regulation (mediated) of Negative_regulation (inhibition) of met-enkephalin in lacrimal
13) Confidence 0.01 Published 1998 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 9660481 Disease Relevance 0 Pain Relevance 0

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