INT261812

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.26
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
nerve 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 120 99.98 Very High Very High Very High
agonist 77 99.98 Very High Very High Very High
substance P 11 99.92 Very High Very High Very High
calcitonin gene related peptide 14 99.64 Very High Very High Very High
analgesia 21 99.40 Very High Very High Very High
Pain 214 98.44 Very High Very High Very High
antagonist 105 95.80 Very High Very High Very High
addiction 6 94.80 High High
Kinase C 20 84.84 Quite High
interstitial cystitis 1 78.16 Quite High
Disease Link Frequency Relevance Heat
Pain 230 98.44 Very High Very High Very High
Overactive Bladder 12 96.96 Very High Very High Very High
Disease 38 90.08 High High
Nociception 50 86.64 High High
Interstitial Cystitis 1 78.16 Quite High
Abnormal Reflex 7 74.40 Quite High
Targeted Disruption 58 70.88 Quite High
INFLAMMATION 49 65.44 Quite High
Stress Incontinence 3 40.44 Quite Low
Asthma 5 25.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravesical administration of capsaicin and RTX, a potent TRPV1 agonist results in a marked decrease in TRPV1, SP and CGRP immunoreactivity in the rat urinary bladder [13, 14], which may be as a result of nerve terminal degeneration mediated by these agents [27, 35, 37, 40, 146, 163].
Positive_regulation (results) of Negative_regulation (decrease) of TRPV1 in nerve associated with calcitonin gene related peptide, qutenza, agonist and substance p
1) Confidence 0.46 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.74 Pain Relevance 0.69
Prolonged or repeated application of capsaicin induces a desensitization of TRPV1, representing analgesia, a paradox in pain biology.
Positive_regulation (induces) of Negative_regulation (desensitization) of TRPV1 associated with pain, qutenza and analgesia
2) Confidence 0.39 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.26 Pain Relevance 0.70
TRPV1 can be desensitized following its activation and desensitization is calcium and phosphorylation-state dependent [212].
Positive_regulation (following) of Negative_regulation (desensitized) of TRPV1
3) Confidence 0.34 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.26 Pain Relevance 0.71

General Comments

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