INT261815

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv2) plasma membrane (Trpv2) intracellular (Trpv2)
transmembrane transport (Trpv2) cytoplasm (Trpv2)
Anatomy Link Frequency
neurons 2
Trpv2 (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 11 97.76 Very High Very High Very High
mu opioid receptor 4 96.96 Very High Very High Very High
nociceptor 78 94.36 High High
Thermal hyperalgesia 9 92.32 High High
hypoalgesia 1 88.80 High High
Dorsal column 2 82.12 Quite High
Dorsal horn 12 81.52 Quite High
Spinal cord 9 78.92 Quite High
Neuropeptide 5 78.04 Quite High
trigeminal ganglion 75 60.24 Quite High
Disease Link Frequency Relevance Heat
Nociception 20 96.84 Very High Very High Very High
Hyperalgesia 27 92.32 High High
Hypoalagesia 1 88.80 High High
Urological Neuroanatomy 2 87.28 High High
Ganglion Cysts 87 60.24 Quite High
Stress Incontinence 1 59.44 Quite High
Targeted Disruption 66 59.24 Quite High
Pain 99 52.68 Quite High
Repression 7 39.24 Quite Low
Fever 2 8.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Trpv1 and Trpv2 is affected only in a subset of high-expressing neurons, while SP, CGRP, Accn3 and the mu opioid receptor (MOR) exhibit normal or increased expression in Runx1 knockouts [7,48].
Regulation (affected) of Gene_expression (Expression) of Trpv2 in neurons associated with calcitonin gene related peptide and mu opioid receptor
1) Confidence 0.32 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.19 Pain Relevance 0.93
However, it is known that TRPV2 expression in trkC subpopulations of adult DRG’s is dependent on NT-3 signaling in development stages [211].
Regulation (dependent) of Gene_expression (expression) of TRPV2
2) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.78 Pain Relevance 0.72

General Comments

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