INT261816

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.16
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 17 99.68 Very High Very High Very High
Hyperalgesia 16 99.16 Very High Very High Very High
induced neuropathy 1 96.52 Very High Very High Very High
Taxol 1 95.76 Very High Very High Very High
allodynia 7 92.68 High High
nociceptor 46 84.44 Quite High
Thermal hyperalgesia 9 83.68 Quite High
Pain 92 80.00 Quite High
cerebral cortex 2 58.96 Quite High
Thalamus 3 57.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 16 99.68 Very High Very High Very High
Hyperalgesia 27 99.16 Very High Very High Very High
Neuropathic Pain 23 96.52 Very High Very High Very High
Nociception 17 89.76 High High
Pain 96 80.00 Quite High
Targeted Disruption 23 75.48 Quite High
Disease 19 52.32 Quite High
Stress 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 7 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, angiotensin stimulation results in ubiquitination of TRPV4, a process that requires ?
Positive_regulation (results) of Localization (ubiquitination) of TRPV4
1) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestin 1 acts as an adaptor for the E3 ubiquitin ligase, AIP4, to facilitate TRPV4 ubiquitination and thus identify ?
Positive_regulation (facilitate) of Localization (ubiquitination) of TRPV4
2) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
These studies have shown that PGE2 and PAR2 mediated sensitization of TRPV4 occurs during inflammatory hyperalgesia.
Positive_regulation (occurs) of Localization (sensitization) of TRPV4 associated with hyperalgesia and inflammation
3) Confidence 0.31 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 1.16 Pain Relevance 1.07

General Comments

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