INT261820

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.41
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lyn) Golgi apparatus (Lyn) plasma membrane (Lyn)
nucleus (Lyn) enzyme binding (Lyn) kinase activity (Lyn)
Anatomy Link Frequency
macrophages 1
THP-1 1
neutrophils 1
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 54 94.88 High High
fibrosis 2 80.48 Quite High
Inflammation 56 75.96 Quite High
nociceptor 46 50.00 Quite Low
qutenza 23 50.00 Quite Low
Nerve growth factor 7 43.76 Quite Low
Kinase C 10 19.56 Low Low
agonist 34 17.16 Low Low
antagonist 37 8.92 Low Low
Pain 92 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 97.60 Very High Very High Very High
Apoptosis 84 92.00 High High
Pressure And Volume Under Development 1 88.52 High High
Fibrosis 2 80.48 Quite High
Asthma 25 79.08 Quite High
Airway Remodeling 2 77.32 Quite High
INFLAMMATION 72 75.96 Quite High
Rhinitis 11 75.16 Quite High
Weight Gain 1 71.00 Quite High
Gastroenteritis 4 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our hands, MSU did not induce Syk or Lyn phosphorylation in PMA-differentiated THP-1 cells nor in BMDM.
Phosphorylation (phosphorylation) of Lyn in THP-1
1) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.06 Pain Relevance 0
However, MSU was previously reported to trigger Syk phosphorylation in dendritic cells [35] and human neutrophils [36], as well as Lyn phosphorylation in neutrophils [37].
Phosphorylation (phosphorylation) of Lyn in neutrophils
2) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.05 Pain Relevance 0
Using BMDM from Lyn-deficient mice, we found that Hz-induced Syk phosphorylation required Lyn, and further confirmed that MSU does not utilize this signaling pathway in either murine or human macrophages (Fig. 5).
Phosphorylation (phosphorylation) of Lyn in macrophages
3) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
blocks tyrosine phosphorylation of Jak2 and Lyn tyrosine kinases.139 Furthermore, it inhibits the activation of ERK MAP kinase and Stat1 nuclear factor.
Phosphorylation (phosphorylation) of Lyn
4) Confidence 0.17 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.10 Pain Relevance 0.20
Lyn, a member of Src-family of tyrosine kinases, mediated tyrosine phosphorylation at Tyr-253 residue to regulate TRPV4 response to hypotonic stress [224, 236].
Phosphorylation (phosphorylation) of Lyn associated with stress
5) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox